Regulation of glycolysis by fructose 2,6-bisphosphate metabolism

Stable Identifier
R-HSA-9634600
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
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Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
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The committed step of glycolysis is the phosphorylation of D-fructose 6-phosphate (Fru(6)P) to form D-fructose 1,6-bisphosphate, catalyzed by phosphofructokinase 1 (PFK) tetramer. PFK can be allosterically activated by D-fructose 2,6-bisphosphate whose levels are increased in response to insulin signaling and decreased in response to glucagon signaling, through the reactions annotated here (Pilkis et al. 1995).

Literature References
PubMed ID Title Journal Year
7574501 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme.

Kurland, IJ, Lange, AJ, Pilkis, SJ, Claus, TH

Annu Rev Biochem 1995
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Event Information
Go Biological Process
regulation of glycolytic process through fructose-6-phosphate (1904538)
Orthologous Events
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Caenorhabditis elegans)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Canis familiaris)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Danio rerio)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Dictyostelium discoideum)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Drosophila melanogaster)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Gallus gallus)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Mus musculus)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Rattus norvegicus)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Saccharomyces cerevisiae)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Schizosaccharomyces pombe)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Sus scrofa)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Xenopus tropicalis)
Reviewed
Harris, RA  (2008-09-10)
Created
D'Eustachio, P  (2019-01-11)
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