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Phosphorylation of PF2K-Pase by PKA catalytic subunit
Stable Identifier
R-HSA-163773
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
PKA-mediated phosphorylation of key metabolic factors (Homo sapiens)
Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Homo sapiens)
Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)
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Activated PKA (protein kinase A) phosphorylates serine 36 of the bifunctional 6-Phosphofructo-2-kinase /Fructose-2,6-bisphosphatase (PFKFB1) enzyme. This phosphorylation inhibits the enzyme's phosphofructokinase (PFK-2) activity while activating its phosphatase activity. As a result, cytosolic levels of Fructose-2,6-bisphosphate (F-2,6-P2) are reduced. F-2,6-P2 in turn is a key positive regulator of the committed step of glycolysis, so the net effect of this phosphorylation event is a reduced rate of glycolysis.
Participants
Input
x 2
ATP [cytosol]
PFKFB1 dimer [cytosol]
(Homo sapiens)
Output
x 2
ADP [cytosol]
x 2
H+ [cytosol]
phosphoPFKFB1 dimer [cytosol]
(Homo sapiens)
Participates
as an event of
PKA-mediated phosphorylation of key metabolic factors (Homo sapiens)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Homo sapiens)
Event Information
Go Biological Process
negative regulation of glycolytic process (0045820)
Catalyst Activity
cAMP-dependent protein kinase activity of PKA catalytic subunit [cytosol]
Physical Entity
PKA catalytic subunit [cytosol]
(Homo sapiens)
Activity
cAMP-dependent protein kinase activity (GO:0004691)
Inferred From
Phosphorylation of rPF2K-Pase by rPKA (Rattus norvegicus)
Cross References
RHEA
17990
Authored
Gopinathrao, G (2005-05-11)
Reviewed
Hill, DP (2024-02-12)
Created
Gopinathrao, G (2005-05-06)
© 2025
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