PRKCZ stimulates RAS nucleotide exchange in response to estrogen

Stable Identifier
Reaction [omitted]
Homo sapiens
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Estrogen stimulation promotes nucleotide exchange on RAS in a number of cell lines, leading to RAS signaling and cell cycle progression (Atkas et al, 1997; Cheng et al, 1998; Kawada et al, 1997; Castoria et al, 1999; Castoria et al, 2001). RAS activation depends on recruitment of SRC, PI3K and PRKCZ, and the complex likely also includes SOS, although this has not been explicitly demonstrated (Migliaccio et al, 1996; Castoria et al, 2004; reviewed in Castoria et al, 2010).
Literature References
PubMed ID Title Journal Year
9199319 Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1

Cooper, GM, Cai, H, Aktas, H

Mol. Cell. Biol. 1997
15314172 Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells

Auricchio, F, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L

Mol. Cell. Biol. 2004
8635462 Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells

Auricchio, F, Bontempo, P, Di Domenico, M, de Falco, A, Nola, E, Castoria, G, Migliaccio, A

EMBO J. 1996
19879889 Cell proliferation regulated by estradiol receptor: Therapeutic implications

Auricchio, F, Giovannelli, P, Castoria, G, Migliaccio, A

Steroids 2010
10228164 Non-transcriptional action of oestradiol and progestin triggers DNA synthesis

Auricchio, F, Migliaccio, A, Castoria, G, Di Domenico, M, Barone, MV, Bilancio, A, Ametrano, D

EMBO J. 1999
9448290 Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

Sexl, V, Sherr, CJ, Cheng, M, Roussel, MF

Proc. Natl. Acad. Sci. U.S.A. 1998
11689445 PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells

Auricchio, F, Fiorentino, R, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L

EMBO J. 2001
9264403 Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway

Uehara, Y, Suzuki, K, Yamagoe, S, Kawada, M, Mizuno, S, Murakami, Y

Oncogene 1997
Orthologous Events
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