Reactome | PRKCZ stimulates RAS nucleotide exchange in response to estrogen

PRKCZ stimulates RAS nucleotide exchange in response to estrogen

Stable Identifier

R-HSA-9632918

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

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PRKCZ stimulates RAS nucleotide exchange in response to estrogen

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Estrogen stimulation promotes nucleotide exchange on RAS in a number of cell lines, leading to RAS signaling and cell cycle progression (Atkas et al, 1997; Cheng et al, 1998; Kawada et al, 1997; Castoria et al, 1999; Castoria et al, 2001). RAS activation depends on recruitment of SRC, PI3K and PRKCZ, and the complex likely also includes SOS, although this has not been explicitly demonstrated (Migliaccio et al, 1996; Castoria et al, 2004; reviewed in Castoria et al, 2010).

Literature References

PubMed ID	Title	Journal	Year
9199319	Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1 Cooper, GM, Cai, H, Aktas, H	Mol. Cell. Biol.	1997
10228164	Non-transcriptional action of oestradiol and progestin triggers DNA synthesis Auricchio, F, Migliaccio, A, Castoria, G, Di Domenico, M, Barone, MV, Bilancio, A, Ametrano, D	EMBO J.	1999
9448290	Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1) Sexl, V, Sherr, CJ, Cheng, M, Roussel, MF	Proc. Natl. Acad. Sci. U.S.A.	1998
15314172	Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells Auricchio, F, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L	Mol. Cell. Biol.	2004
11689445	PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells Auricchio, F, Fiorentino, R, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L	EMBO J.	2001
8635462	Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells Auricchio, F, Bontempo, P, Di Domenico, M, de Falco, A, Nola, E, Castoria, G, Migliaccio, A	EMBO J.	1996
19879889	Cell proliferation regulated by estradiol receptor: Therapeutic implications Auricchio, F, Giovannelli, P, Castoria, G, Migliaccio, A	Steroids	2010
9264403	Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway Uehara, Y, Suzuki, K, Yamagoe, S, Kawada, M, Mizuno, S, Murakami, Y	Oncogene	1997