Estrogen-stimulated signaling through PRKCZ

Stable Identifier
R-HSA-9634635
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Estrogen-stimulated signaling through PRKCZ
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Atypical protein kinases lack the calcium binding C2 domain and are unresponsive to diacylglycerol and phorbol ester, but instead respond to PIP3 generation downstream of PI3K signaling. Atypical protein kinase C zeta (PRKCZ) is activated downstream of estrogen stimulation is MCF7 breast cancer cells and contributes estrogen-dependent proliferation through MAPK pathway activation (Castoria et al, 2004).
Literature References
PubMed ID Title Journal Year
15314172 Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells

Auricchio, F, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L

Mol. Cell. Biol. 2004
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Cross References
BioModels Database
Authored
Rothfels, K  (2018-12-15)
Reviewed
Levin, ER  (2019-02-20)
Marino, M  (2019-04-24)
Acconcia, F  (2019-04-24)
Created
Rothfels, K  (2019-01-12)
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