BCL gene expression downstream of ESR1

Stable Identifier
Reaction [omitted]
Homo sapiens
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BCL2 mRNA and protein levels increase in response to E2 stimulation in a PKA-dependent manner (Grimaldi et al, 2002; Yune et al, 2008). Levels of phosphorylated CREB1 also increase with estrogen stimulation, however direct binding of phosphorylated CREB to the BCL2 promoter has not been demonstrated. Estrogen-dependent BCL2 expression is also dependent on Sp1 (Dong et al, 1999; Yune et al, 2008; reviewed in Ladikou and Kassi, 2017).

Literature References
PubMed ID Title Journal Year
18785877 Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation

Yune, TY, Park, HG, Oh, TH, Lee, JY

J. Neurotrauma 2008
10542244 Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells

Dong, L, Stoner, M, Vyhlidal, C, Kladde, MP, Samudio, I, Wang, W, Safe, S, Harigai, M, Reed, JC, Wang, F

J. Biol. Chem. 1999
12070310 Estrogen alters thresholds for B cell apoptosis and activation

Diamond, B, Cleary, J, Moussai, D, Grimaldi, CM, Dagtas, AS

J. Clin. Invest. 2002
27557932 The emerging role of estrogen in B cell malignancies

Kassi, E, Ladikou, EE

Leuk. Lymphoma 2017
This event is regulated