Reactome | ID1 and ID3 gene expression

ID1 and ID3 gene expression

Stable Identifier

R-HSA-9613460

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        ID1 and ID3 gene expression (Homo sapiens)

General

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ID1-4 (Inhibitor of DNA-binding) are members of the helix-loop-helix family of proteins that lack the basic amino acids responsible for DNA binding in basic HLH proteins. HLH domain-mediated heterodimerization of an ID protein with a basic HLH protein therefore acts as a natural dominant negative inhibitor of bHLH function by preventing DNA binding (Massari and Murre, 2000). ID proteins primarily interact with members of the E family of proteins, including E12, E47, HEB and E2-2, but also interact with other bHLH proteins. ID proteins promote cell cycle progression and cell migration, and restrict cellular senescence and the differentiation of a number of progenitor cell types, including oligodendrocytes (reviewed in Perk et al, 2005; Ling et al, 2014). ID1 and ID3 proteins also have established roles in hematopoiesis (Nogueira et al, 2000; Rivera and Murre, 2001; Hong et al, 2011; Zhao et al, 2016).
ID1 and ID3 gene expression is activated by the binding of CREB1 to CRE sites in the promoter. CREB recruits transcriptional co-activators p300 and CBP in a CREB S133 phosphorylation-dependent manner (reviewed in Shaywitz and Greenberg, 1999). ID1 and ID3 gene activation also depends on the CREB1-dependent recruitment of LYL1, a basic helix-loop-helix transcription factor with roles in cell proliferation and differentiation. The N-terminal domain of LYL1 interacts with the Q2 and KID domains of CREB1 in a manner that does not require CREB1 S133 phosphorylation (San Marina et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
18160048	Lyl1 interacts with CREB1 and alters expression of CREB1 target genes San-Marina, S, Han, Y, Suarez Saiz, F, Trus, MR, Minden, MD	Biochim. Biophys. Acta	2008
21486943	ID1 and ID3 represent conserved negative regulators of human embryonic and induced pluripotent stem cell hematopoiesis Hong, SH, Lee, JH, Lee, JB, Ji, J, Bhatia, M	J. Cell. Sci.	2011
27128622	Combined Id1 and Id3 Deletion Leads to Severe Erythropoietic Disturbances Zhao, Q, Chang, C, Gonzalez, JP, Alzahrani, K, Button, JL, Fraidenraich, D	PLoS ONE	2016
10872467	CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals Shaywitz, AJ, Greenberg, ME	Annu. Rev. Biochem.	1999
11840323	The regulation and function of the Id proteins in lymphocyte development Rivera, R, Murre, C	Oncogene	2001
11027551	Regulation of Id gene expression during embryonic stem cell-derived hematopoietic differentiation Nogueira, MM, Mitjavila-Garcia, MT, Le Pesteur, F, Filippi, MD, Vainchenker, W, Dubart Kupperschmitt, A, Sainteny, F	Biochem. Biophys. Res. Commun.	2000