Reactome | Biosynthesis of maresin conjugates in tissue regeneration (MCTR)

Biosynthesis of maresin conjugates in tissue regeneration (MCTR)

Stable Identifier

R-HSA-9026762

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Biosynthesis of maresin conjugates in tissue regeneration (MCTR)

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Resolution of inflammation is carried out by endogenous mediators termed specialised proresolving mediators (SPMs). Macrophages are central to the acute inflammatory response, governing both initiation and resolution phases, depending on the macrophage subtype activated. Human macrophages involved in resolution produce a family of bioactive peptide-conjugated mediators called maresin conjugates in tissue regeneration (MCTR). These mediators stimulate human phagocytotic functions, promote the resolution of bacterial infections, counterregulate the production of proinflammatory mediators and promote tissue repair and regeneration (Dalli et al. 2016). The proposed biosynthetic pathway is as follows. The maresin epoxide intermediate 13(S),14(S)-epoxy-MaR (13(S),14(S)-epoxy-docosahexaenoic acid) can be converted to MCTR1 (13(R)-glutathionyl, 14(S)-hydroxy-docosahexaenoic acid) by LTC4S and GSTM4. MCTR1 can be converted to MCTR2 (13(R)-cysteinylglycinyl, 14(S)-hydroxy-docosahexaenoic acid) by γ-glutamyl transferase (GGT). Finally, a dipeptidase can cleave the cysteinyl-glycinyl bond of MCTR2 to give MCTR3 (13(R)-cysteinyl, 14(S)-hydroxy-docosahexaenoic acid) (Dalli et al. 2016, Serhan et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
27791009	Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages Dalli, J, Vlasakov, I, Riley, IR, Rodriguez, AR, Spur, BW, Petasis, NA, Chiang, N, Serhan, CN	Proc. Natl. Acad. Sci. U.S.A.	2016
28802833	New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration Serhan, CN, Chiang, N, Dalli, J	Mol. Aspects Med.	2017