LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1

Stable Identifier
Reaction [transition]
Homo sapiens
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Trimeric leukotriene C4 synthase (LTC4S trimer), located on the ER membrane, can catalyse the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid (13(S),14(S)-epoxy-DHA) to form maresin conjugates in tissue regeneration 1 (MCTR1) (Dalli et al. 2014, 2016a, 2016b). Incubation of human macrophages with LTC4S inhibitors significantly reduces cysteinyl leukotriene production and increases resolvin and lipoxin production (Dalli et al. 2016a). MCTR1, given to mice with E. coli peritonitis, showed potent proresolving action in inflammation and infections. With human macrophages, MCTR1 stimulated efferocytosis of apoptotic cells (Dalli et al. 2014).

Literature References
PubMed ID Title Journal Year
27791009 Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

Riley, IR, Serhan, CN, Rodriguez, AR, Petasis, NA, Chiang, N, Spur, BW, Vlasakov, I, Dalli, J

Proc. Natl. Acad. Sci. U.S.A. 2016
25324525 Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

Serhan, CN, Chiang, N, Dalli, J

Proc. Natl. Acad. Sci. U.S.A. 2014
26881986 Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3

Serhan, CN, Sanger, JM, Rodriguez, AR, Chiang, N, Spur, BW, Dalli, J

PLoS ONE 2016
Catalyst Activity

glutathione transferase activity of LTC4S trimer [endoplasmic reticulum membrane]

Orthologous Events
Cross References
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