LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1

Stable Identifier
R-HSA-9026780
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Trimeric leukotriene C4 synthase (LTC4S trimer), located on the ER membrane, can catalyse the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid (13(S),14(S)-epoxy-DHA) to form maresin conjugates in tissue regeneration 1 (MCTR1) (Dalli et al. 2014, 2016a, 2016b). Incubation of human macrophages with LTC4S inhibitors significantly reduces cysteinyl leukotriene production and increases resolvin and lipoxin production (Dalli et al. 2016a). MCTR1, given to mice with E. coli peritonitis, showed potent proresolving action in inflammation and infections. With human macrophages, MCTR1 stimulated efferocytosis of apoptotic cells (Dalli et al. 2014).

Literature References
PubMed ID Title Journal Year
25324525 Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

Dalli, J, Chiang, N, Serhan, CN

Proc. Natl. Acad. Sci. U.S.A. 2014
27791009 Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

Dalli, J, Vlasakov, I, Riley, IR, Rodriguez, AR, Spur, BW, Petasis, NA, Chiang, N, Serhan, CN

Proc. Natl. Acad. Sci. U.S.A. 2016
26881986 Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3

Dalli, J, Sanger, JM, Rodriguez, AR, Chiang, N, Spur, BW, Serhan, CN

PLoS ONE 2016
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutathione transferase activity of LTC4S trimer [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!