Reactome | LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1

LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1

Stable Identifier

R-HSA-9026780

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione => (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
    - Biosynthesis of DHA-derived SPMs (Homo sapiens)
      - Biosynthesis of DHA-derived sulfido conjugates (Homo sapiens)
        
        Biosynthesis of maresin conjugates in tissue regeneration (MCTR) (Homo sapiens)
        
        LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Homo sapiens)

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LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1

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Trimeric leukotriene C4 synthase (LTC4S trimer), located on the ER membrane, can catalyse the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid (13(S),14(S)-epoxy-DHA) to form maresin conjugates in tissue regeneration 1 (MCTR1) (Dalli et al. 2014, 2016a, 2016b). Incubation of human macrophages with LTC4S inhibitors significantly reduces cysteinyl leukotriene production and increases resolvin and lipoxin production (Dalli et al. 2016a). MCTR1, given to mice with E. coli peritonitis, showed potent proresolving action in inflammation and infections. With human macrophages, MCTR1 stimulated efferocytosis of apoptotic cells (Dalli et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
27791009	Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages Dalli, J, Vlasakov, I, Riley, IR, Rodriguez, AR, Spur, BW, Petasis, NA, Chiang, N, Serhan, CN	Proc. Natl. Acad. Sci. U.S.A.	2016
25324525	Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection Dalli, J, Chiang, N, Serhan, CN	Proc. Natl. Acad. Sci. U.S.A.	2014
26881986	Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3 Dalli, J, Sanger, JM, Rodriguez, AR, Chiang, N, Spur, BW, Serhan, CN	PLoS ONE	2016