DPEP hydrolyses MCTR2 to MCTR3

Stable Identifier
R-HSA-9026771
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
DPEP hydrolyses MCTR2 to MCTR3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In human macrophages, a dipeptidase (DPEP) is proposed to hydrolyse maresin conjugates in tissue regeneration 2 (MCTR2) to MCTR3, identified as 13(R)-cysteinyl, 14(S)-hydroxy-4Z,7Z,9E,11E,13R,14S,16Z,19Zdocosahexaenoic acid (Dalli et al. 2014, 2016a, 2016b). Incubation of human macrophages with MCTR2 and a DPEP inhibitor demonstrates significantly higher MCTR2 levels and significantly lower MCTR3 levels, suggesting a DPEP mediates MCTR2 hydrolysis (Dalli et al. 2016a). MCTR3 displays potent activity in proresolution of inflammation and tissue regeneration (Dalli et al. 2016b).
Literature References
PubMed ID Title Journal Year
27791009 Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

Riley, IR, Serhan, CN, Rodriguez, AR, Petasis, NA, Chiang, N, Spur, BW, Vlasakov, I, Dalli, J

Proc. Natl. Acad. Sci. U.S.A. 2016
25324525 Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

Serhan, CN, Chiang, N, Dalli, J

Proc. Natl. Acad. Sci. U.S.A. 2014
26881986 Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3

Serhan, CN, Sanger, JM, Rodriguez, AR, Chiang, N, Spur, BW, Dalli, J

PLoS ONE 2016
Participants
Input
Output
Participates
as an event of
Catalyst Activity

dipeptidase activity of DPEP [cytosol]

Physical Entity
DPEP [cytosol] (Homo sapiens)
Activity
dipeptidase activity (GO:0016805)
Cross References
RHEA
Rhea
Authored
Jassal, B  (2017-10-23)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-10-23)
Cite Us!