DPEP hydrolyses MCTR2 to MCTR3

Stable Identifier
R-HSA-9026771
Type
Reaction [transition]
Species
Homo sapiens
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In human macrophages, a dipeptidase (DPEP) is proposed to hydrolyse maresin conjugates in tissue regeneration 2 (MCTR2) to MCTR3, identified as 13(R)-cysteinyl, 14(S)-hydroxy-4Z,7Z,9E,11E,13R,14S,16Z,19Zdocosahexaenoic acid (Dalli et al. 2014, 2016a, 2016b). Incubation of human macrophages with MCTR2 and a DPEP inhibitor demonstrates significantly higher MCTR2 levels and significantly lower MCTR3 levels, suggesting a DPEP mediates MCTR2 hydrolysis (Dalli et al. 2016a). MCTR3 displays potent activity in proresolution of inflammation and tissue regeneration (Dalli et al. 2016b).

Literature References
PubMed ID Title Journal Year
25324525 Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

Dalli, J, Chiang, N, Serhan, CN

Proc. Natl. Acad. Sci. U.S.A. 2014
27791009 Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

Dalli, J, Vlasakov, I, Riley, IR, Rodriguez, AR, Spur, BW, Petasis, NA, Chiang, N, Serhan, CN

Proc. Natl. Acad. Sci. U.S.A. 2016
26881986 Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3

Dalli, J, Sanger, JM, Rodriguez, AR, Chiang, N, Spur, BW, Serhan, CN

PLoS ONE 2016
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Catalyst Activity
Title
dipeptidase activity of DPEP [cytosol]
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Activity
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Rhea
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