GGT hydrolyses MCTR1 to MCTR2

Stable Identifier
R-HSA-9026757
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E16S,17S-epoxy-DHA ,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate
ReviewStatus
5/5
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GGT hydrolyses MCTR1 to MCTR2
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In human macrophages, a glutathione hydrolase (GGT) is proposed to cleave the γ-glutamyl moiety of MCTR1 to yield MCTR2, identified as 13(R)-cysteinylglycinyl, 14(S)-hydroxy-docosahexaenoic acid (Dalli et al. 2014, 2016a, 2016b). Incubation of human macrophages with MCTR1 and GGT enzyme inhibitors significantly reduces MCTR2 and MCTR3 production and significantly increases MCTR1 amounts, suggesting a GGT mediates MCTR2 production (Dalli et al. 2016a). In addition, Dalli et al. found the human recombinant GGT used in the experiment has a higher affinity for MCTR1 than leukotriene C4 (Dalli et al. 2016a). MCTR2, given to mice with E. coli peritonitis, showed potent proresolving action in inflammation and infections. With human macrophages, MCTR2 proved to be more potent that MCTR1 in stimulating efferocytosis of apoptotic cells (Dalli et al. 2014).
Literature References
PubMed ID Title Journal Year
27791009 Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

Riley, IR, Serhan, CN, Rodriguez, AR, Petasis, NA, Chiang, N, Spur, BW, Vlasakov, I, Dalli, J

Proc. Natl. Acad. Sci. U.S.A. 2016
25324525 Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

Serhan, CN, Chiang, N, Dalli, J

Proc. Natl. Acad. Sci. U.S.A. 2014
26881986 Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3

Serhan, CN, Sanger, JM, Rodriguez, AR, Chiang, N, Spur, BW, Dalli, J

PLoS ONE 2016
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glutathione hydrolase activity of GGT [cytosol]

Physical Entity
GGT [cytosol] (Homo sapiens)
Activity
glutathione hydrolase activity (GO:0036374)
Cross References
RHEA
Rhea
Authored
Jassal, B  (2017-10-23)
Reviewed
Hansen, TV  (2018-02-21)
Created
Jassal, B  (2017-10-23)
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