Reactome | HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1

HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1

Stable Identifier

R-HSA-9024766

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NAD(+) + resolvin D1 => 17-oxoresolvin D1 + H(+) + NADH, NAD(+) + resolvin D1 => 8-oxoresolvin D1 + H(+) + NADH

ReviewStatus

5/5

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HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1

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Cytosolic, dimeric 15-hydroxyprostaglandin dehydrogenase (HPGD dimer), in the presence of NAD+, can oxidise 17(S)-resolvin D1 (RvD1) to the novel metabolites 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1. The 17(S)-oxo transformation effectively inactivates RvD1 activity whereas the 8-oxo metabolite retains most of its RvD1 activity (Sun et al. 2007). The epimeric 17(R) aspirin-triggered form (AT-RvD1) was also found to be able to resist rapid inactivation.

Literature References

PubMed ID	Title	Journal	Year
17244615	Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation Sun, YP, Oh, SF, Uddin, J, Yang, R, Gotlinger, K, Campbell, E, Colgan, SP, Petasis, NA, Serhan, CN	J. Biol. Chem.	2007