HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1

Stable Identifier
R-HSA-9024766
Type
Reaction [transition]
Species
Homo sapiens
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Cytosolic, dimeric 15-hydroxyprostaglandin dehydrogenase (HPGD dimer), in the presence of NAD+, can oxidise 17(S)-resolvin D1 (RvD1) to the novel metabolites 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1. The 17(S)-oxo transformation effectively inactivates RvD1 activity whereas the 8-oxo metabolite retains most of its RvD1 activity (Sun et al. 2007). The epimeric 17(R) aspirin-triggered form (AT-RvD1) was also found to be able to resist rapid inactivation.

Literature References
PubMed ID Title Journal Year
17244615 Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation

Sun, YP, Oh, SF, Uddin, J, Yang, R, Gotlinger, K, Campbell, E, Colgan, SP, Petasis, NA, Serhan, CN

J. Biol. Chem. 2007
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Catalyst Activity
Title
15-hydroxyprostaglandin dehydrogenase (NAD+) activity of HPGD dimer [cytosol]
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Activity
Orthologous Events
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