Reactome | p-Y-INPP5D [cytosol]

p-Y-INPP5D [cytosol]

Stable Identifier

R-HSA-9680730

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 ecNumber evidence="9 17 18"3.1.3.86/ecNumber, SHIP1_HUMAN

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External Reference Information

External Reference

UniProt:Q92835 INPP5D

Gene Names

INPP5D, SHIP, SHIP1

Chain

chain:1-1189

Reference Genes

BioGPS Gene:3635 INPP5D

COSMIC (genes):INPP5D INPP5D

CTD Gene:3635 INPP5D

dbSNP Gene:3635 INPP5D

ENSEMBL:ENSG00000168918 INPP5D

HGNC:6079 INPP5D

KEGG:hsa:3635 INPP5D

Monarch:3635 INPP5D

NCBI Gene:3635 INPP5D

OMIM:601582 INPP5D

UCSC:Q92835 INPP5D

Reference Transcript

Participates

as a component of

LYN:p-Y-INPP5D [cytosol] (Homo sapiens)

Other forms of this molecule

INPP5D [cytosol]

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_005532.2, NP_001017915.1

Guide to Pharmacology - Targets

1455

OpenTargets

ENSG00000168918

ENSEMBL

ENSP00000352575, ENST00000629761, ENSP00000405338, ENST00000445964, ENSG00000168918, ENST00000630854, ENSG00000281614, ENSP00000486669, ENSP00000487191, ENST00000359570

IntEnz

3.1.3.36, 3.1.3.86

HPA

ENSG00000168918-INPP5D

GeneCards

INPP5D

PRO

Q92835

Pharos - Targets

Q92835

GlyGen

Q92835

HMDB Protein

HMDBP03787

PDB

2YSX, 5RWP, 5RY3, 5RXG, 5RW3, 5RWI, 5RW7, 8PDG, 5RYJ, 5RWZ, 5RWW, 5RWB, 5RY7, 5RWU, 5RY5, 5RYL, 5RWJ, 5RWY, 5RY9, 5RXP, 5RWF, 5RX0, 5RXD, 5RYF, 5RWS, 5RW4, 5RXR, 5RX2, 5RXH, 8UM5, 5RXY, 5RW8, 5RYK, 5RXV, 5RWC, 5RX5, 5RYB, 5RWK, 5RY0, 5RWA, 5RXE, 8PDI, 5RWG, 5RX7, 5RXX, 5RXM, 5RWO, 5RYG, 5RX3, 5RXT, 5RY2, 5RXI, 5RW5, 5RXZ, 5RWQ, 5RXA, 5RW9, 5RY6, 5RXK, 5RWL, 5RY4, 5RYH, 5RYC, 5RWT, 5RY8, 5RWN, 5RXF, 5RXO, 5RX9, 8PDH, 5RWV, 5RWD, 5RWR, 5RYD, 5RXJ, 5RXQ, 5RXB, 5RW2, 5RX1, 5RWH, 5RW6, 5RXU, 5RXL, 5RWM, 5RYI, 5RXS, 5RX6, 5RWX, 5RXW, 6IBD, 5RY1, 8PDJ, 5RX8, 5RXC, 6XY7, 5RWE, 5RYA, 5RX4, 5RYE

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31994 FCGR2B	1	FCGR2B [plasma membrane] (R-HSA-197854)	0.702	3
UniProt:Q9BZW8 CD244	1	CD244 [plasma membrane] (R-HSA-197846)	0.667	6
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:O75525 KHDRBS3	2	KHDRSB3 [nucleoplasm] (R-HSA-8849040) p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:P19235 EPOR	2	p-8Y-EPOR [plasma membrane] (R-HSA-9006274) EPOR [plasma membrane] (R-HSA-1168347)	0.547	2
UniProt:Q13291 SLAF1			0.462	2

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