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p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane]
Stable Identifier
R-HSA-9006306
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI3K bound to EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
Erythropoietin activates Phospholipase C gamma (PLCG) (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PLCG1,2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-PLCG1,2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PLCG1,2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-PLCG1,2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
Erythropoietin activates RAS (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:SOS1,p-Y-VAV1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:p-Y-VAV1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:p-Y-VAV1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
Erythropoietin activates STAT5 (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:STAT5 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:STAT5 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-STAT5 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-STAT5 [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
Phospho-JAK2 phosphorylates EPOR (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
Participants
components
x 2
IRS2 [cytosol]
(Homo sapiens)
x 2
LYN [cytosol]
(Homo sapiens)
x 2
p-12Y-JAK2 [cytosol]
(Homo sapiens)
x 2
p-8Y-EPOR [plasma membrane]
(Homo sapiens)
Participates
as a component of
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)
Inferred From
p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 [plasma membrane]
(Mus musculus)
Inferred To
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane]
(Bos taurus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane]
(Canis familiaris)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane]
(Drosophila melanogaster)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane]
(Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane]
(Rattus norvegicus)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane]
(Sus scrofa)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane]
(Xenopus tropicalis)
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