RASA1 stimulates RAS GTPase activity

Stable Identifier
R-HSA-8981353
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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RASA1 stimulates RAS GTPase activity
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The intrinsic GTPase activity of RAS proteins is stimulated by the GAP protein RASA1 (reviewed in King et al, 2013).
Literature References
PubMed ID Title Journal Year
23443682 Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis

King, PD, Lubeck, BA, Lapinski, PE

Sci Signal 2013
Participants
Input
Output
Participates
as an event of
Catalyst Activity

GTPase activity of p21 RAS:GTP:RASA1 [plasma membrane]

Physical Entity
p21 RAS:GTP:RASA1 [plasma membrane] (Homo sapiens)
Activity
GTPase activity (GO:0003924)
This event is regulated
Negatively by
Regulator
p-Y1105-ARHGAP35:RASA1 [cytosol] (Homo sapiens)
Active Unit
p-Y1105-ARHGAP35 [cytosol]
Orthologous Events
RASA1 stimulates RAS GTPase activity (Bos taurus)
RASA1 stimulates RAS GTPase activity (Canis familiaris)
RASA1 stimulates RAS GTPase activity (Danio rerio)
RASA1 stimulates RAS GTPase activity (Dictyostelium discoideum)
RASA1 stimulates RAS GTPase activity (Drosophila melanogaster)
RASA1 stimulates RAS GTPase activity (Gallus gallus)
RASA1 stimulates RAS GTPase activity (Mus musculus)
RASA1 stimulates RAS GTPase activity (Rattus norvegicus)
RASA1 stimulates RAS GTPase activity (Sus scrofa)
RASA1 stimulates RAS GTPase activity (Xenopus tropicalis)
Authored
Rothfels, K  (2014-12-10)
Reviewed
Roskoski, R Jr  (2015-04-29)
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2017-03-05)
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