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p-Y1105-ARHGAP35 [cytosol]
Stable Identifier
R-HSA-8849056
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-Y1105-p190RhoGAP
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
ARHGAP35 binds RASA1 (Homo sapiens)
p-Y1105-ARHGAP35 [cytosol] (Homo sapiens)
p-Y1105-ARHGAP35:RASA1 [cytosol] (Homo sapiens)
p-Y1105-ARHGAP35 [cytosol] (Homo sapiens)
ARHGAP35 binds RHOA:GTP (Homo sapiens)
p-Y1105-ARHGAP35 [cytosol] (Homo sapiens)
p-Y1105-ARHGAP35:RHOA:GTP [cytosol] (Homo sapiens)
p-Y1105-ARHGAP35 [cytosol] (Homo sapiens)
ARHGAP35 stimulates RHOA GTPase activity (Homo sapiens)
p-Y1105-ARHGAP35 [cytosol] (Homo sapiens)
p-Y1105-ARHGAP35:RHOA:GTP [cytosol] (Homo sapiens)
p-Y1105-ARHGAP35 [cytosol] (Homo sapiens)
PTK6 phosphorylates ARHGAP35 (Homo sapiens)
p-Y1105-ARHGAP35 [cytosol] (Homo sapiens)
RASA1 stimulates RAS GTPase activity (Homo sapiens)
p-Y1105-ARHGAP35 [cytosol] (Homo sapiens)
p-Y1105-ARHGAP35:RASA1 [cytosol] (Homo sapiens)
p-Y1105-ARHGAP35 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NRY4 ARHGAP35
Gene Names
ARHGAP35, GRF1, GRLF1, KIAA1722, P190A, p190ARHOGAP
Chain
chain:1-1499
Reference Genes
BioGPS Gene:2909 ARHGAP35
COSMIC (genes):ARHGAP35 ARHGAP35
CTD Gene:2909 ARHGAP35
dbSNP Gene:2909 ARHGAP35
ENSEMBL:ENSG00000160007 ARHGAP35
HGNC:4591 ARHGAP35
KEGG:hsa:2909 ARHGAP35
Monarch:2909 ARHGAP35
NCBI Gene:2909 ARHGAP35
OMIM:605277 ARHGAP35
UCSC:Q9NRY4 ARHGAP35
Reference Transcript
RefSeq:XM_017026714.1 ARHGAP35
RefSeq:NM_004491.4 ARHGAP35
Other Identifiers
11725420_at
11725421_a_at
11725422_s_at
11746448_a_at
11748374_a_at
1565881_3p_at
1565881_PM_at
1565881_at
16863521
16863534
202044_PM_at
202044_at
202045_PM_s_at
202045_s_at
202046_PM_s_at
202046_s_at
229394_3p_s_at
229394_PM_s_at
229394_s_at
2909
34724_at
34725_at
3836980
3837002
3837003
3837004
3837005
3837006
3837007
3837011
3837017
3837018
3837019
3837034
3837035
3837036
3837042
3837043
3837044
3837045
3837046
3837047
3837048
3837049
3837050
3837051
3837052
3837053
3837054
3837055
3837056
3837057
3837058
3837059
3837060
3837061
3837062
3837063
3837064
3837069
3837071
3837073
3837075
53559_at
8029856
A_14_P128858
A_23_P39137
A_24_P36299
A_24_P44845
A_33_P3367481
GE58056
GO:0001843
GO:0003013
GO:0003677
GO:0003824
GO:0003924
GO:0005096
GO:0005525
GO:0005543
GO:0005634
GO:0005737
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0007010
GO:0007163
GO:0007165
GO:0007266
GO:0007411
GO:0007413
GO:0008064
GO:0008289
GO:0008360
GO:0008361
GO:0010976
GO:0015629
GO:0016477
GO:0016787
GO:0021955
GO:0030879
GO:0030900
GO:0030950
GO:0032956
GO:0035024
GO:0036064
GO:0042995
GO:0043010
GO:0043116
GO:0043226
GO:0044319
GO:0045724
GO:0048856
GO:0048870
GO:0050770
GO:0051056
GO:0097485
GO:0098772
HMNXSV003049975
Hs.102548.0.A2_3p_at
Hs.102548.0.A3_3p_a_at
Hs.102548.2.A1_3p_a_at
Hs.102548.2.A1_3p_at
Hs2.378706.1.S1_3p_at
Hs2.378706.1.S1_3p_x_at
ILMN_1658145
ILMN_1687362
ILMN_1696845
M73077_at
PH_hs_0005686
TC19000669.hg
TC19000670.hg
g4758481_3p_a_at
Participates
as an output of
ARHGAP35 stimulates RHOA GTPase activity (Homo sapiens)
PTK6 phosphorylates ARHGAP35 (Homo sapiens)
as a component of
p-Y1105-ARHGAP35:RHOA:GTP [cytosol] (Homo sapiens)
p-Y1105-ARHGAP35:RASA1 [cytosol] (Homo sapiens)
as an input of
ARHGAP35 binds RHOA:GTP (Homo sapiens)
ARHGAP35 binds RASA1 (Homo sapiens)
Other forms of this molecule
ARHGAP35 [cytosol]
Inferred To
phospho-ARHGAP35 [cytosol]
(Bos taurus)
phospho-ARHGAP35 [cytosol]
(Sus scrofa)
phospho-RhoGAPp190 [cytosol]
(Drosophila melanogaster)
phospho-p-Y1105-ARHGAP35 [cytosol]
(Canis familiaris)
phospho-p-Y1105-ARHGAP35 [cytosol]
(Gallus gallus)
phospho-p-Y1105-ARHGAP35 [cytosol]
(Mus musculus)
phospho-p-Y1105-ARHGAP35 [cytosol]
(Rattus norvegicus)
phospho-rga-5 [cytosol]
(Caenorhabditis elegans)
phospho-arhgap35 [cytosol]
(Xenopus tropicalis)
phospho-arhgap35a [cytosol]
(Danio rerio)
Modified Residues
Name
O4'-phospho-L-tyrosine at 1105
Coordinate
1105
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
ENSEMBL
ENST00000672722
,
ENSG00000160007
,
ENSP00000500409
OpenTargets
ENSG00000160007
GeneCards
ARHGAP35
HPA
ENSG00000160007-ARHGAP35
PRO
Q9NRY4
Pharos - Targets
Q9NRY4
PDB
3FK2
,
8DGQ
,
6WAY
,
6PXC
,
2K85
,
3C5H
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05120 SERPINB2
2
SERPINB2 [plasma membrane]
(R-HSA-159004)
SERPINB2 [extracellular region]
(R-HSA-158997)
0.527
2
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