Reactome | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

Stable Identifier

R-HSA-8849471

Type

Pathway

Species

Homo sapiens

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

Click the image above or here to open this pathway in the Pathway Browser

PTK6 promotes cell motility and migration by regulating the activity of RHO GTPases RAC1 (Chen et al. 2004) and RHOA (Shen et al. 2008). PTK6 inhibits RAS GTPase activating protein RASA1 (Shen et al. 2008) and may be involved in MAPK7 (ERK5) activation (Ostrander et al. 2007, Zheng et al. 2012)

Literature References

PubMed ID	Title	Journal	Year
15572663	Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin Chen, HY, Shen, CH, Tsai, YT, Lin, FC, Huang, YP, Chen, RH	Mol. Cell. Biol.	2004
17483331	Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells Ostrander, JH, Daniel, AR, Lofgren, K, Kleer, CG, Lange, CA	Cancer Res.	2007
22084245	Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate Zheng, Y, Asara, JM, Tyner, AL	J. Biol. Chem.	2012
18829532	Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion Shen, CH, Chen, HY, Lin, MS, Li, FY, Chang, CC, Kuo, ML, Settleman, J, Chen, RH	Cancer Res.	2008