PTK6 promotes cell motility and migration by regulating the activity of RHO GTPases RAC1 (Chen et al. 2004) and RHOA (Shen et al. 2008). PTK6 inhibits RAS GTPase activating protein RASA1 (Shen et al. 2008) and may be involved in MAPK7 (ERK5) activation (Ostrander et al. 2007, Zheng et al. 2012)
Chen, HY, Shen, CH, Tsai, YT, Lin, FC, Huang, YP, Chen, RH
Ostrander, JH, Daniel, AR, Lofgren, K, Kleer, CG, Lange, CA
Zheng, Y, Asara, JM, Tyner, AL
Shen, CH, Chen, HY, Lin, MS, Li, FY, Chang, CC, Kuo, ML, Settleman, J, Chen, RH
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