Reactome | Chylomicron assembly

Chylomicron assembly

Stable Identifier

R-HSA-8963888

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

Chylomicrons transport triacylglycerol, phospholipid, and cholesterol derived from dietary lipid from the small intestine to other tissues of the body. Each chylomicron assembles around a single molecule of apolipoprotein B-48 (Phillips et al. 1997) which at the time the particle leaves the intestine and enters the lymphatic circulation is complexed with >200,000 molecules of triacylglycerol (TG), ~35,000 of phospholipid, ~11,000 of cholesterol ester, ~8,000 of free cholesterol, ~60 copies of apolipoprotein A-I, ~15 copies of apolipoprotein A-IV, and copies of apolipoprotein A-II (Bhattacharya and Redgrave 1981).

Literature References

PubMed ID	Title	Journal	Year
7288288	The content of apolipoprotein B in chylomicron particles Bhattacharya, S, Redgrave, TG	J Lipid Res	1981
9215545	A single copy of apolipoprotein B-48 is present on the human chylomicron remnant Phillips, ML, Pullinger, C, Kroes, I, Kroes, J, Hardman, DA, Chen, G, Curtiss, LK, Gutierrez, MM, Kane, JP, Schumaker, VN	J Lipid Res	1997