Chylomicron assembly

Stable Identifier
R-HSA-8963888
Type
Pathway
Species
Homo sapiens
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Chylomicron assembly
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Chylomicrons transport triacylglycerol, phospholipid, and cholesterol derived from dietary lipid from the small intestine to other tissues of the body. Each chylomicron assembles around a single molecule of apolipoprotein B-48 (Phillips et al. 1997) which at the time the particle leaves the intestine and enters the lymphatic circulation is complexed with >200,000 molecules of triacylglycerol (TG), ~35,000 of phospholipid, ~11,000 of cholesterol ester, ~8,000 of free cholesterol, ~60 copies of apolipoprotein A-I, ~15 copies of apolipoprotein A-IV, and copies of apolipoprotein A-II (Bhattacharya and Redgrave 1981).

Literature References
PubMed ID Title Journal Year
9215545 A single copy of apolipoprotein B-48 is present on the human chylomicron remnant

Phillips, ML, Pullinger, C, Kroes, I, Kroes, J, Hardman, DA, Chen, G, Curtiss, LK, Gutierrez, MM, Kane, JP, Schumaker, VN

J Lipid Res 1997
7288288 The content of apolipoprotein B in chylomicron particles

Bhattacharya, S, Redgrave, TG

J Lipid Res 1981
Participants
Events
Participant Of
hasEvent
Event Information
Go Biological Process
chylomicron assembly (0034378)
Orthologous Events
Chylomicron assembly (Bos taurus)
Chylomicron assembly (Canis familiaris)
Chylomicron assembly (Danio rerio)
Chylomicron assembly (Mus musculus)
Chylomicron assembly (Rattus norvegicus)
Chylomicron assembly (Sus scrofa)
Chylomicron assembly (Xenopus tropicalis)
Cross References
BioModels Database
Authored
D'Eustachio, P  (2006-02-20)
Reviewed
Jassal, B  (2016-01-27)
Created
D'Eustachio, P  (2017-02-13)