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Degradation of newly synthesized ApoB-48
Stable Identifier
R-HSA-174731
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
ReviewStatus
5/5
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Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein assembly (Homo sapiens)
Chylomicron assembly (Homo sapiens)
Degradation of newly synthesized ApoB-48 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Newly synthesized apoB-48 that is not complexed with lipid is rapidly degraded (Dixon et al. 1991). The mechanism and site of this degradation (within the endoplasmic reticulum or in cytosolic proteasomes) is unclear.
Literature References
PubMed ID
Title
Journal
Year
1848237
Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B
Ginsberg, HN
,
Furukawa, S
,
Dixon, JL
J Biol Chem
1991
Participants
Input
APOB(28-2179) [endoplasmic reticulum lumen]
(Homo sapiens)
Participates
as an event of
Chylomicron assembly (Homo sapiens)
Orthologous Events
Degradation of newly synthesized ApoB-48 (Bos taurus)
Degradation of newly synthesized ApoB-48 (Canis familiaris)
Degradation of newly synthesized ApoB-48 (Gallus gallus)
Degradation of newly synthesized ApoB-48 (Mus musculus)
Degradation of newly synthesized ApoB-48 (Rattus norvegicus)
Degradation of newly synthesized ApoB-48 (Sus scrofa)
Authored
D'Eustachio, P (2007-04-30)
Created
D'Eustachio, P (2006-02-20)
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