Reactome | nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]

nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]

Stable Identifier

R-HSA-174587

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Exocytosis of nascent chylomicrons

ReviewStatus

5/5

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nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]

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While the export pathway for nascent chylomicrons has not been directly characterized in human cells, the requirement for SAR1B protein for normal chylomicron export in vivo (Jones et al. 2003) indicates that nascent chylomicrons are exported from the endoplasmic reticulum via the Golgi apparatus in COPII vesicles.

Literature References

PubMed ID	Title	Journal	Year
12692552	Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders Jones, B, Jones, EL, Bonney, SA, Patel, HN, Mensenkamp, AR, Eichenbaum-Voline, S, Rudling, M, Myrdal, U, Annesi, G, Naik, S, Meadows, N, Quattrone, A, Islam, SA, Naoumova, RP, Angelin, B, Infante, R, Levy, E, Roy, CC, Freemont, PS, Scott, J, Shoulders, CC	Nat Genet	2003