Tyrosine catabolism

Stable Identifier
R-HSA-8963684
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Tyrosine catabolism
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Cytosolic tyrosine is transaminated to form 3-(4-hydroxyphenyl)pyruvate which in four further reactions is converted to fumarate and acetoacetate. Tyrosine is thus both a glucogenic (fumarate) and a ketogenic (acetoacetate) amino acid. Defects in any of the steps lead to metabolic diseases with accumulation of tyrosine (tyrosinemia) (Mitchell et al. 2001; Held, 2006).
Literature References
PubMed ID Title Journal Year
16773741 Disorders of tyrosine catabolism

Held, PK

Mol Genet Metab 2006
  The Metabolic and Molecular Bases of Inherited Disease, 8th ed

Beaudet, AL, Scriver, CR, Sly, WS, Valle, D

  2001
Participants
Events
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as an event of
Event Information
Go Biological Process
tyrosine catabolic process (0006572)
Orthologous Events
Tyrosine catabolism (Bos taurus)
Tyrosine catabolism (Caenorhabditis elegans)
Tyrosine catabolism (Canis familiaris)
Tyrosine catabolism (Danio rerio)
Tyrosine catabolism (Dictyostelium discoideum)
Tyrosine catabolism (Drosophila melanogaster)
Tyrosine catabolism (Gallus gallus)
Tyrosine catabolism (Mus musculus)
Tyrosine catabolism (Rattus norvegicus)
Tyrosine catabolism (Sus scrofa)
Tyrosine catabolism (Xenopus tropicalis)
Authored
Jassal, B  (2017-02-10)
Created
Jassal, B  (2017-02-10)
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