maleylacetoacetate => fumarylacetoacetate

Stable Identifier
R-HSA-71173
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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Cytosolic maleylacetoacetic acid isomerase (GSTZ1) catalyzes the conversion of 4-maleylacetoacetate to 4-fumarylacetoacetate. The enzyme is a homodimer (Polekhina et al. 2001).

Literature References
PubMed ID Title Journal Year
11327815 Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity.

Polekhina, G, Board, PG, Blackburn, AC, Parker, MW

Biochemistry 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
maleylacetoacetate isomerase activity of GSTZ1 dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored