Reactome | GSTZ1 isomerizes 4-MAA

GSTZ1 isomerizes 4-MAA

Stable Identifier

R-HSA-71173

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

4-maleylacetoacetate => 4-fumarylacetoacetate, maleylacetoacetate => fumarylacetoacetate

ReviewStatus

5/5

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Cytosolic maleylacetoacetic acid isomerase (MAAI, GSTZ1) catalyzes the conversion of 4-maleylacetoacetate to 4-fumarylacetoacetate. The enzyme is a homodimer, requiring one glutathione (GSH) molecule per monomer as cofactor (Polekhina et al. 2001; Board et al., 2003; Boone et al., 2014).

Literature References

PubMed ID	Title	Journal	Year
11327815	Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity. Polekhina, G, Board, PG, Blackburn, AC, Parker, MW	Biochemistry	2001
24637752	Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a) Boone, CD, Zhong, G, Smeltz, M, James, MO, McKenna, R	Acta Crystallogr F Struct Biol Commun	2014
12852784	Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique Board, PG, Taylor, MC, Coggan, M, Parker, MW, Lantum, HB, Anders, MW	Biochem J	2003