fumarylacetoacetate => fumarate + acetoacetate

Stable Identifier
R-HSA-71181
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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This is the final step of tyrosine degradation. Fumarylacetoacetase catalyzes the hydrolysis of 4-fumarylacetoacetate to form fumarate and acetoacetate (Labelle et al. 1993).

Literature References
PubMed ID Title Journal Year
8364576 Characterization of the human fumarylacetoacetate hydrolase gene and identification of a missense mutation abolishing enzymatic activity.

Labelle, Y, Phaneuf, D, Leclerc, B, Tanguay, RM

Hum Mol Genet 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
fumarylacetoacetase activity of FAH dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored