fumarylacetoacetate => fumarate + acetoacetate

Stable Identifier
R-HSA-71181
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
fumarylacetoacetate => fumarate + acetoacetate
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

This is the final step of tyrosine degradation. Fumarylacetoacetase catalyzes the hydrolysis of 4-fumarylacetoacetate to form fumarate and acetoacetate (Labelle et al. 1993).

Literature References
PubMed ID Title Journal Year
8364576 Characterization of the human fumarylacetoacetate hydrolase gene and identification of a missense mutation abolishing enzymatic activity.

Labelle, Y, Phaneuf, D, Leclerc, B, Tanguay, RM

Hum Mol Genet 1993
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
fumarylacetoacetase activity of FAH dimer [cytosol]
Physical Entity
FAH dimer [cytosol]
Activity
fumarylacetoacetase activity (0004334)
Orthologous Events
fumarylacetoacetate => fumarate + acetoacetate (Bos taurus)
fumarylacetoacetate => fumarate + acetoacetate (Caenorhabditis elegans)
fumarylacetoacetate => fumarate + acetoacetate (Canis familiaris)
fumarylacetoacetate => fumarate + acetoacetate (Danio rerio)
fumarylacetoacetate => fumarate + acetoacetate (Dictyostelium discoideum)
fumarylacetoacetate => fumarate + acetoacetate (Drosophila melanogaster)
fumarylacetoacetate => fumarate + acetoacetate (Gallus gallus)
fumarylacetoacetate => fumarate + acetoacetate (Mus musculus)
fumarylacetoacetate => fumarate + acetoacetate (Rattus norvegicus)
fumarylacetoacetate => fumarate + acetoacetate (Sus scrofa)
fumarylacetoacetate => fumarate + acetoacetate (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2003-06-24)
Cite Us!