Cytosolic 4-hydroxyphenylpyruvate dioxygenase (HPD) catalyzes the reaction of 3-(4-Hydroxyphenyl)pyruvate with molecular oxygen to form homogentisate and CO2 (Ruetschi et al. 2000, Lindblad et al. 1970). Unpublished crystallographic data indicate that the enzyme is a homodimer (PDB 3ISQ) utilising Fe2+ and ascorbate (AscH-).
Lindblad, B, Lindstedt, S, Lindstedt, G
Schiaffino, MC, Standing, S, Pérez-Cerda, C, Rüetschi, U, Holme, E, Ugarte, M, Cerone, R
4-hydroxyphenylpyruvate dioxygenase activity of HPD:AscH-:Fe2+ dimer [cytosol]
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