Reactome | p-MIA3 [endoplasmic reticulum lumen]

p-MIA3 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8957064

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

MIA3, Melanoma inhibitory activity protein 3, MIA3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q5JRA6 MIA3

Gene Names

MIA3, KIAA0268, TANGO, UNQ6077/PRO20088

Chain

signal peptide:1-22, chain:23-1907

Reference Genes

BioGPS Gene:375056 MIA3

COSMIC (genes):MIA3 MIA3

CTD Gene:375056 MIA3

dbSNP Gene:375056 MIA3

ENSEMBL:ENSG00000154305.18 MIA3

HGNC:24008 MIA3

KEGG Gene (Homo sapiens):375056 MIA3

Monarch:375056 MIA3

NCBI Gene:375056 MIA3

OMIM:613455 MIA3

UCSC:Q5JRA6 MIA3

Reference Transcript

Other Identifiers

11722906_a_at

11722907_at

11752439_s_at

1569057_3p_s_at

1569057_PM_s_at

1569057_s_at

16677748

212305_PM_s_at

212305_s_at

212310_PM_at

212310_at

2381795

2381797

2381798

2381799

2381800

2381801

2381802

2381803

2381811

2381812

2381813

2381816

2381821

2381822

2381823

2381824

2381825

2381827

2381828

2381829

2381830

2381831

2381833

2381834

2381836

2381838

2381840

2381842

2381844

2381846

2381851

2381854

2381855

2381856

2381857

2381866

2381867

2381869

2381871

3498228

375056

39563_at

4042694

4042695

4042816

4042818

4042819

4042820

4042821

4042823

4042825

4042827

4042841

4042842

4042843

4042846

4042849

4042850

4042851

4042852

4042853

4042855

4042856

4042857

4042858

4042859

4042861

4042862

4042864

4042866

4042868

4042870

4042871

4042873

4042879

4042882

4042883

4042884

4042890

4042892

4042894

4043063

4043120

4043123

4043124

4043125

4043126

4043127

4043128

4045302

4045303

4045305

4045306

4045307

4045308

4045309

7909898

A_24_P255516

A_24_P256692

A_33_P3236632

A_33_P3236642

A_33_P3236646

D87742_at

GO:0002042

GO:0002376

GO:0002687

GO:0005515

GO:0005783

GO:0005788

GO:0005789

GO:0006887

GO:0006888

GO:0006897

GO:0007029

GO:0007155

GO:0007162

GO:0009306

GO:0015031

GO:0016020

GO:0016192

GO:0030336

GO:0035459

GO:0038024

GO:0042060

GO:0042953

GO:0043226

GO:0043231

GO:0048856

GO:0048870

GO:0061024

GO:0070971

GO:0070973

GO:0090110

GO:0140052

GO:1903038

GO:2000402

HMNXSV003010857

Hs.241552.0.S1_3p_a_at

Hs.241552.0.S2_3p_at

ILMN_2312906

PH_hs_0036969

TC01001829.hg

Participates

as a member of

FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

MIA3 [endoplasmic reticulum membrane]

MIA3 [endoplasmic reticulum lumen]

Inferred To

phospho-MIA3 [endoplasmic reticulum lumen] (Bos taurus)

phospho-MIA3 [endoplasmic reticulum lumen] (Sus scrofa)

phospho-Tango1 [endoplasmic reticulum lumen] (Drosophila melanogaster)

phospho-Mia3 [endoplasmic reticulum lumen] (Mus musculus)

phospho-Mia3 [endoplasmic reticulum lumen] (Rattus norvegicus)

phospho-p-MIA3 [endoplasmic reticulum lumen] (Canis familiaris)

phospho-p-MIA3 [endoplasmic reticulum lumen] (Danio rerio)

phospho-p-MIA3 [endoplasmic reticulum lumen] (Gallus gallus)

phospho-mia3 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_940953.2, NP_001287796.1, NP_001310992.1

OpenTargets

ENSG00000154305

HPA

ENSG00000154305-MIA3

GeneCards

Q5JRA6

Ensembl

ENSP00000345866, ENST00000344922, ENST00000340535, ENSP00000340900, ENSG00000154305

PRO

Q5JRA6

Pharos - Targets

Q5JRA6

PDB

5KYU, 5KYW, 5KYN

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95833 CLIC3			0.556	3
UniProt:Q96PV6 LENG8			0.556	3
UniProt:Q9NSC5 HOMER3	1	HOMER3 [cytosol] (R-HSA-6794236)	0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:Q15436 SEC23A	4	p-S738,T744 SEC23A [cytosol] (R-HSA-5685740) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) SEC23A [cytosol] (R-HSA-203972) SEC23A [endoplasmic reticulum membrane] (R-HSA-203976)	0.556	3
UniProt:Q02388 COL7A1	20	3x4Hyp-3Hyp-5Hyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605704) 5Hyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605706) 3x4Hyp-3Hyp-COL7A1(2822-2944) [extracellular region] (R-HSA-3605690) 3x4Hyp-5Hyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605707) 3x4Hyp-3Hyp-GalHyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605709) COL7A1(2822-2944) [extracellular region] (R-HSA-3605694) 3x4Hyp-GlcGalHyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605696) 3x4Hyp-GalHyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605698) 3x4Hyp-COL7A1(2822-2944) [extracellular region] (R-HSA-3605699) 3x4Hyp-3Hyp-GlcGalHyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605700) GlcGalHyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605687) GalHyl-COL7A1(2822-2944) [extracellular region] (R-HSA-3605703) COL7A1 [extracellular region] (R-HSA-2127487) 3x4Hyp-3Hyp-GlcGalHyl-COL7A1 [extracellular region] (R-HSA-2127471) GalHyl-COL7A1 [extracellular region] (R-HSA-2127517) 3x4Hyp-3Hyp-COL7A1 [extracellular region] (R-HSA-2127485) 3x4Hyp-COL7A1 [extracellular region] (R-HSA-2127530) 3x4Hyp-5Hyl-COL7A1 [extracellular region] (R-HSA-2127496) GlcGalHyl-COL7A1 [extracellular region] (R-HSA-2127478) 3x4Hyp-3Hyp-5Hyl-COL7A1 [extracellular region] (R-HSA-2127525)	0.524	2
UniProt:Q9BPX1 HSD17B14	1	HSD17B14 [cytosol] (R-HSA-6810587)	0.488	2