RUNX3 binds to complexes of beta-catenin (CTNNB1) and TCF/LEF family members. Binding of RUNX3 to CTNNB1:TCF/LEF complexes prevents their loading onto cyclin D1 (CCND1) and MYC gene promoters and interferes with WNT signaling-mediated activation of CCND1 and MYC1 transcription. RUNX3 therefore inhibits WNT-induced cellular proliferation (Ito et al. 2008).
Ito, Y, Osato, M, Voon, DC, Lee, CW, Salto-Tellez, M, Fukamachi, H, Motoda, L, Chuang, LS, Wang, H, Ito, K, Lim, AC, Koo, JK
© 2022 Reactome
