Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1

Stable Identifier
R-HSA-8951443
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Binding of the complex of beta-catenin (CTNNB1) and TCF7L2 (TCF4) or LEF1 transcription factors to TCF/LEF binding sites in the promoter of the cyclin D1 (CCND1) gene stimulates CCND1 transcription (Tetsu and McCormick 1999, Shtutman et al. 1999).
Literature References
PubMed ID Title Journal Year
10318916 The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

Shtutman, M, Albanese, C, D'Amico, M, Zhurinsky, J, Simcha, I, Pestell, R, Ben-Ze'ev, A

Proc. Natl. Acad. Sci. U.S.A. 1999
10201372 Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

McCormick, F, Tetsu, O

Nature 1999
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