TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene

Stable Identifier
R-HSA-4411367
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TCF7L1 (also known as TCF3), TCF7L3 (also known as LEF1) and TCF7L2 (also known as TCF4) have been demonstrated to bind to the MYC gene in vivo and in vitro and to mediate beta-catenin dependent transcription (Park et al, 2009; He et al, 1998; Sierra et al, 2006). Aberrant beta-catenin dependent activation of the MYC gene contributes to oncogenic signaling and cellular proliferation in colorectal and other cancers (see for instance Sansom et al, 2007; Moumen et al, 2013; reviewed in Wilkins and Sansom, 2008; Cairo et al, 2012).
Binding of RUNX3 to the CTNNB1:TCF7L2 and possibly to the CTNNB1:LEF1 and TCF7L1 complexes, prevents binding of CTNNB1 complexes to the MYC promoter, thus negatively regulating MYC transcription (Ito et al. 2008).

Literature References
PubMed ID Title Journal Year
16510874 The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes

Sierra, J, Yoshida, T, Joazeiro, CA, Jones, KA

Genes Dev. 2006
22201888 Activation of Wnt and Myc signaling in hepatoblastoma

Cairo, S, Armengol, C, Buendia, MA

Front Biosci (Elite Ed) 2012
24171719 Myc is required for ?-catenin-mediated mammary stem cell amplification and tumorigenesis

Moumen, M, Chiche, A, Decraene, C, Petit, V, Gandarillas, A, Deugnier, MA, Glukhova, MA, Faraldo, MM

Mol. Cancer 2013
17377531 Myc deletion rescues Apc deficiency in the small intestine

Sansom, OJ, Meniel, VS, Muncan, V, Phesse, TJ, Wilkins, JA, Reed, KR, Vass, JK, Athineos, D, Clevers, HC, Clarke, AR

Nature 2007
9727977 Identification of c-MYC as a target of the APC pathway

He, TC, Sparks, AB, Rago, C, Hermeking, H, Zawel, L, da Costa, LT, Morin, PJ, Vogelstein, B, Kinzler, KW

Science 1998
19571879 Telomerase modulates Wnt signalling by association with target gene chromatin

Park, JI, Venteicher, AS, Hong, JY, Choi, J, Jun, S, Shkreli, M, Chang, W, Meng, Z, Cheung, P, Ji, H, McLaughlin, M, Veenstra, TD, Nusse, R, McCrea, PD, Artandi, SE

Nature 2009
18593890 C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine

Wilkins, JA, Sansom, OJ

Cancer Res. 2008
18772112 RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis

Ito, K, Lim, AC, Salto-Tellez, M, Motoda, L, Osato, M, Chuang, LS, Lee, CW, Voon, DC, Koo, JK, Wang, H, Fukamachi, H, Ito, Y

Cancer Cell 2008
Participants
Participant Of
This event is regulated
Authored
Reviewed
Created