CTNNB1:TCF7L2,LEF1 binds the CCND1 gene promoter

Stable Identifier
R-HSA-8951442
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CTNNB1:TCF7L2,LEF1 binds the CCND1 gene promoter
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Beta-catenin (CTNNB1), in complex with TCF7L2 (TCF4) or LEF1, binds to TCF/LEF binding sites in the promoter of the cyclin D1 (CCND1) gene (Tetsu and McCormick 1999, Shtutman et al. 1999). Binding of RUNX3 to the CTNNB1:TCF7L2 and possibly to the CTNNB1:LEF1 complex, prevents binding of CTNNB1 complexes to the CCND1 promoter, thus negatively regulating CCND1 transcription (Ito et al. 2008).
Literature References
PubMed ID Title Journal Year
10318916 The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

Shtutman, M, Albanese, C, D'Amico, M, Zhurinsky, J, Simcha, I, Pestell, R, Ben-Ze'ev, A

Proc. Natl. Acad. Sci. U.S.A. 1999
18772112 RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis

Ito, Y, Osato, M, Voon, DC, Lee, CW, Salto-Tellez, M, Fukamachi, H, Motoda, L, Chuang, LS, Wang, H, Ito, K, Lim, AC, Koo, JK

Cancer Cell 2008
10201372 Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

McCormick, F, Tetsu, O

Nature 1999
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
RUNX3:CTNNB1:TCF7L2,(LEF1) [nucleoplasm] (Homo sapiens)
Active Unit
RUNX3:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-12-02)
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