Reactome | RNF181 [cytoplasm]

RNF181 [cytoplasm]

Stable Identifier

R-HSA-8939317

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytoplasm

Synonyms

E3 ubiquitin-protein ligase RNF181 ecNumber6.3.2.-/ecNumber, RN181_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
18331836	RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3 Daxecker, H, Lehmann, I, Brophy, TM, Treumann, A, Moran, N, Raab, M, Culligan, KG, Chubb, AJ	Biochem. Biophys. Res. Commun.	2008

External Reference Information

External Reference

UniProt:Q9P0P0 RNF181

Gene Names

RNF181, HSPC238

Chain

chain:1-153

Reference Genes

BioGPS Gene:51255 RNF181

COSMIC (genes):RNF181 RNF181

CTD Gene:51255 RNF181

dbSNP Gene:51255 RNF181

ENSEMBL:ENSG00000168894 RNF181

HGNC:28037 RNF181

Monarch:51255 RNF181

NCBI Gene:51255 RNF181

OMIM:612490 RNF181

UCSC:Q9P0P0 RNF181

Reference Transcript

RefSeq:NM_016494.3 RNF181

Other Identifiers

11716443_at

16882291

223064_PM_at

223064_at

2491687

2491688

2491689

2491690

2491691

2491692

2491693

2491694

2491695

2491696

2491697

2491698

2491699

2491700

3017787

3017794

51255

56469_at

8043209

A_14_P136901

A_23_P108708

GE54924

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0016567

GO:0016740

GO:0046872

GO:0051865

GO:0061630

GO:0140096

HMNXSV003047218

ILMN_1655340

PH_hs_0001087

PH_hs_0030989

TC02000514.hg

g7106865_3p_at

Participates

as an input of

RNF181 binds BCL10 and Ubiquitin:E2 (Homo sapiens)

as an output of

RNF181 polyubiquinates BCL10 (Homo sapiens)

as a component of

RNF181:BCL10:Ub:E2 [cytoplasm] (Homo sapiens)

Inferred To

RNF181 [cytoplasm] (Bos taurus)

RNF181 [cytoplasm] (Canis familiaris)

RNF181 [cytoplasm] (Dictyostelium discoideum)

RNF181 [cytoplasm] (Sus scrofa)

Ghost homologue of RNF181 [cytoplasm] (Gallus gallus)

Ghost homologue of RNF181 [cytoplasm] (Xenopus tropicalis)

Rnf181 [cytoplasm] (Mus musculus)

Rnf181 [cytoplasm] (Rattus norvegicus)

rnf181 [cytoplasm] (Danio rerio)

Cross References

ENSEMBL

ENST00000306368, ENSP00000306906

OpenTargets

ENSG00000168894

IntEnz

2.3.2.27

HPA

ENSG00000168894-RNF181

PRO

Q9P0P0

Pharos - Targets

Q9P0P0

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51668 UBE2D1	3	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160)	0.666	4
UniProt:Q9Y2X8 UBE2D4	1	UBE2D4 [cytosol] (R-HSA-947623)	0.666	4
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	3
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.527	2
UniProt:Q9H598 SLC32A1	3	SLC32A1 [synaptic vesicle membrane] (R-HSA-936481) SLC32A1 [plasma membrane] (R-HSA-917998) SLC32A1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-428551)	0.527	2
UniProt:Q86V24 ADIPOR2	1	ADIPOR2 [plasma membrane] (R-HSA-8848545)	0.527	2
UniProt:P32320 CDA	5	CDA [cytosol] (R-HSA-73461) CDA [ficolin-1-rich granule lumen] (R-HSA-6801411) CDA [tertiary granule lumen] (R-HSA-6801377) CDA [extracellular region] (R-HSA-6801593) CDA [secretory granule lumen] (R-HSA-6801382)	0.527	2
UniProt:O60427 FADS1	1	FADS1 [endoplasmic reticulum membrane] (R-HSA-400122)	0.527	2
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	3
UniProt:Q8NCS7 SLC44A5	1	SLC44A5 [plasma membrane] (R-HSA-444459)	0.527	2

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