Reactome | RNF181 [cytoplasm]

RNF181 [cytoplasm]

Stable Identifier

R-HSA-8939317

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytoplasm

Synonyms

E3 ubiquitin-protein ligase RNF181 ecNumber6.3.2.-/ecNumber, RN181_HUMAN

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
18331836	RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3 Brophy, TM, Raab, M, Daxecker, H, Culligan, KG, Lehmann, I, Chubb, AJ, Treumann, A, Moran, N	Biochem. Biophys. Res. Commun.	2008

External Reference Information

External Reference

UniProt:Q9P0P0 RNF181

Gene Names

RNF181, HSPC238

Chain

chain:1-153

Reference Genes

BioGPS Gene:51255 RNF181

COSMIC (genes):RNF181 RNF181

CTD Gene:51255 RNF181

dbSNP Gene:51255 RNF181

ENSEMBL:ENSG00000168894 RNF181

HGNC:28037 RNF181

KEGG:hsa:51255 RNF181

Monarch:51255 RNF181

NCBI Gene:51255 RNF181

OMIM:612490 RNF181

UCSC:Q9P0P0 RNF181

Reference Transcript

RefSeq:NM_016494.4 RNF181

Other Identifiers

11716443_at

16882291

223064_PM_at

223064_at

229932_PM_at

229932_at

2491687

2491688

2491689

2491690

2491691

2491692

2491693

2491694

2491695

2491696

2491697

2491698

2491699

2491700

2491701

3017787

3017794

51255

56469_at

57831_s_at

8043209

A_14_P136901

A_23_P108708

A_24_P795283

GE54924

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0008270

GO:0016567

GO:0016740

GO:0046872

GO:0051865

GO:0061630

GO:0140096

HMNXSV003047218

Hs.284394.2.A1_3p_at

ILMN_1655340

PH_hs_0001087

PH_hs_0030989

TC02000514.hg

g7106865_3p_at

Participates

as an input of

RNF181 binds BCL10 and Ubiquitin:E2 (Homo sapiens)

as an output of

RNF181 polyubiquinates BCL10 (Homo sapiens)

as a component of

RNF181:BCL10:Ub:E2 [cytoplasm] (Homo sapiens)

Inferred To

RNF181 [cytoplasm] (Bos taurus)

RNF181 [cytoplasm] (Canis familiaris)

RNF181 [cytoplasm] (Drosophila melanogaster)

RNF181 [cytoplasm] (Sus scrofa)

Ghost homologue of RNF181 [cytoplasm] (Gallus gallus)

Ghost homologue of RNF181 [cytoplasm] (Xenopus tropicalis)

Rnf181 [cytoplasm] (Mus musculus)

Rnf181 [cytoplasm] (Rattus norvegicus)

rnf181 [cytoplasm] (Danio rerio)

Cross References

RefSeq

NP_057578.1

ENSEMBL

ENSG00000168894, ENSP00000306906, ENST00000306368

OpenTargets

ENSG00000168894

GeneCards

RNF181

HPA

ENSG00000168894-RNF181

PRO

Q9P0P0

Pharos - Targets

Q9P0P0

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51668 UBE2D1	4	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160) Ub-C85-UBE2D1 [nucleoplasm] (R-HSA-8937534)	0.666	4
UniProt:Q9Y2X8 UBE2D4	1	UBE2D4 [cytosol] (R-HSA-947623)	0.666	4
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	3
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.527	2
UniProt:Q9H598 SLC32A1	3	SLC32A1 [synaptic vesicle membrane] (R-HSA-936481) SLC32A1 [plasma membrane] (R-HSA-917998) SLC32A1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-428551)	0.527	2
UniProt:Q86V24 ADIPOR2	1	ADIPOR2 [plasma membrane] (R-HSA-8848545)	0.527	2
UniProt:P32320 CDA	5	CDA [ficolin-1-rich granule lumen] (R-HSA-6801411) CDA [secretory granule lumen] (R-HSA-6801382) CDA [extracellular region] (R-HSA-6801593) CDA [tertiary granule lumen] (R-HSA-6801377) CDA [cytosol] (R-HSA-73461)	0.527	2
UniProt:O60427 FADS1	1	FADS1 [endoplasmic reticulum membrane] (R-HSA-400122)	0.527	2
UniProt:P28065 PSMB9	3	PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	3
UniProt:Q8NCS7 SLC44A5	1	SLC44A5 [plasma membrane] (R-HSA-444459)	0.527	2
UniProt:Q86WA8 LONP2	3	LONP2 [cytosol] (R-HSA-391291) LONP2 [peroxisomal matrix] (R-HSA-9033144) LONP2 [cytosol] (R-HSA-8963025)	0.527	2
UniProt:Q9BRB3 PIGQ			0.527	2

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