RNF181 polyubiquinates BCL10

Stable Identifier
R-HSA-8939335
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytoplasm
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RNF181 polyubiquinates BCL10
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The ubiquitin E3 ligase RNF181 transfers ubiquitin from the E2-ubiquitin conjugate (UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2B, or UBE2N) to BCL10 (Pedersen et al. 2015). RNF181, which can interact with CARD11, appears to act on BCL10 before BCL10 is recruited to activated (phosphorylated) CARD11. The resulting lysine-48 polyubiquitinated BCL10 is degraded by the proteasome, resulting in attenuation of T cell receptor signaling downstream of CARD11 (Pedersen et al. 2015).

Literature References
PubMed ID Title Journal Year
26711259 Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181

Pedersen, SM, Chan, W, Jattani, RP, Mackie, dS, Pomerantz, JL

Mol. Cell. Biol. 2016
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Catalyst Activity

ubiquitin protein ligase activity of RNF181:BCL10:Ub:E2 [cytoplasm]

Physical Entity
RNF181:BCL10:Ub:E2 [cytoplasm] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
RNF181 polyubiquinates BCL10 (Bos taurus)
RNF181 polyubiquinates BCL10 (Canis familiaris)
RNF181 polyubiquinates BCL10 (Mus musculus)
RNF181 polyubiquinates BCL10 (Rattus norvegicus)
RNF181 polyubiquinates BCL10 (Sus scrofa)
Authored
May, B  (2016-09-17)
Reviewed
Pomerantz, JL  (2016-10-18)
Created
May, B  (2016-09-18)
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