Reactome | GGC-RAB32 [melanosome membrane]

GGC-RAB32 [melanosome membrane]

Stable Identifier

R-HSA-8877737

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

melanosome membrane

Synonyms

Ras-related protein Rab-32, RAB32_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13637 RAB32

Gene Names

RAB32

Chain

initiator methionine:, chain:2-225

Reference Genes

BioGPS Gene:10981 RAB32

COSMIC (genes):RAB32 RAB32

CTD Gene:10981 RAB32

dbSNP Gene:10981 RAB32

ENSEMBL:ENSG00000118508 RAB32

ENSEMBL_homo_sapiens_GENE:ENSG00000118508.5 RAB32

HGNC:9772 RAB32

KEGG Gene (Homo sapiens):10981 RAB32

Monarch:10981 RAB32

NCBI Gene:10981 RAB32

OMIM:612906 RAB32

UCSC:Q13637 RAB32

Reference Transcript

RefSeq:NM_006834.4 RAB32

Other Identifiers

10981

11719411_at

17013404

204214_PM_s_at

204214_s_at

2929708

2929709

2929716

2929718

2929719

2929720

41523_at

8122554

A_14_P103113

A_23_P42375

A_24_P303480

GE59269

GO:0000166

GO:0002376

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005737

GO:0005739

GO:0005741

GO:0005768

GO:0005769

GO:0005783

GO:0005794

GO:0005802

GO:0005829

GO:0006886

GO:0007005

GO:0012505

GO:0016020

GO:0016192

GO:0016787

GO:0019882

GO:0030154

GO:0030670

GO:0030742

GO:0031410

GO:0031982

GO:0032438

GO:0033162

GO:0035646

GO:0035650

GO:0035651

GO:0036461

GO:0042470

GO:0043226

GO:0043231

GO:0044233

GO:0045335

GO:0072657

GO:0090382

GO:1903232

HMNXSV003012868

ILMN_2115434

PH_hs_0002729

TC06001065.hg

U59878_at

g5803132_3p_at

Participates

as a member of

RAB32,RAB38 [melanosome membrane] (Homo sapiens)

Other forms of this molecule

GGC-RAB32 [cytosol]

RAB32 [cytosol]

Inferred To

rab32a [melanosome membrane] (Danio rerio)

Rab32 [melanosome membrane] (Drosophila melanogaster)

glo-1 [melanosome membrane] (Caenorhabditis elegans)

GGC-RAB32 [melanosome membrane] (Dictyostelium discoideum)

GGC-RAB32 [melanosome membrane] (Mus musculus)

GGC-RAB32 [melanosome membrane] (Saccharomyces cerevisiae)

RAB32 [melanosome membrane] (Bos taurus)

RAB32 [melanosome membrane] (Gallus gallus)

Modified Residues

Name

S-geranylgeranyl-L-cysteine at 224

Coordinate

224

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Name

S-geranylgeranyl-L-cysteine at 225

Coordinate

225

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Cross References

RefSeq

NP_006825.1

Guide to Pharmacology - Targets

3292

OpenTargets

ENSG00000118508

HPA

ENSG00000118508-RAB32

GeneCards

Q13637

Ensembl

ENSG00000118508, ENST00000367495, ENSP00000356465

PRO

Q13637

Pharos - Targets

Q13637

PDB

4CYM, 5OED, 5OEC, 4CZ2, 6FF8

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.753	12
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.544	2
UniProt:Q92696 RABGGTA	2	RABGGTA [plasma membrane] (R-HSA-6801086) RABGGTA [cytosol] (R-HSA-8870418)	0.527	4
UniProt:P24386 CHM	1	CHM [cytosol] (R-HSA-6801097)	0.527	4