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SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane]
Stable Identifier
R-HSA-372544
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-sculpted monoamine transport vesicle membrane
Synonyms
Vesicular monoamine transporter VMAT2
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Dopamine Neurotransmitter Release Cycle (Homo sapiens)
Dopamine synaptic vesicle docking and priming (Homo sapiens)
Docked dopamine loaded synaptic vesicle [plasma membrane] (Homo sapiens)
Dopamine loaded synaptic vesicle [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
Dopamine loaded synaptic vesicle [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
Loading of dopamine into synaptic veiscles (Homo sapiens)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
Release of docked dopamine loaded synaptic vesicle (Homo sapiens)
Docked dopamine loaded synaptic vesicle [plasma membrane] (Homo sapiens)
Dopamine loaded synaptic vesicle [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
Norepinephrine Neurotransmitter Release Cycle (Homo sapiens)
Loading of dopamine into synaptic veiscles (Homo sapiens)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
Noradrenalin synaptic vesicle docking and priming (Homo sapiens)
Docked Noradrenalin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
Noradrenalin loaded synaptic vesicle [clathrin-coated endocytic vesicle] (Homo sapiens)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
Noradrenalin loaded synaptic vesicle [clathrin-coated endocytic vesicle] (Homo sapiens)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
Release of noradrenaline at the synapse (Homo sapiens)
Docked Noradrenalin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
Noradrenalin loaded synaptic vesicle [clathrin-coated endocytic vesicle] (Homo sapiens)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
Serotonin Neurotransmitter Release Cycle (Homo sapiens)
Release of docked serotonin loaded synaptic vesicle (Homo sapiens)
Docked serotonin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
Serotonin loaded synaptic vesicle [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
Serotonin loaded synaptic vesicle docking and priming (Homo sapiens)
Docked serotonin loaded synaptic vesicle [plasma membrane] (Homo sapiens)
Serotonin loaded synaptic vesicle [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
Serotonin loaded synaptic vesicle [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
loading of Serotonin in synaptic vesicles (Homo sapiens)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)
VMAT1/2 can mediate the transport of biogenic amines (Homo sapiens)
VMAT1/2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q05940 SLC18A2
Gene Names
SLC18A2, SVMT, VMAT2
Chain
chain:1-514
Reference Genes
BioGPS Gene:6571 SLC18A2
COSMIC (genes):SLC18A2 SLC18A2
CTD Gene:6571 SLC18A2
dbSNP Gene:6571 SLC18A2
ENSEMBL:ENSG00000165646 SLC18A2
HGNC:10935 SLC18A2
KEGG:hsa:6571 SLC18A2
Monarch:6571 SLC18A2
NCBI Gene:6571 SLC18A2
OMIM:193001 SLC18A2
UCSC:Q05940 SLC18A2
Reference Transcript
RefSeq:NM_003054.4 SLC18A2
Other Identifiers
11734588_a_at
11759609_at
1553328_PM_a_at
1553328_a_at
16709713
205857_PM_at
205857_at
3266285
3266288
3266289
3266292
3266294
3266295
3266296
3266297
3266299
3266301
3266303
3266305
3266311
3266312
3266314
3266317
3266318
3266322
3266323
3266324
3266326
35854_at
53644_at
6571
7930837
A_23_P52499
A_32_P127599
GO:0001975
GO:0002552
GO:0002553
GO:0005215
GO:0005335
GO:0005515
GO:0005813
GO:0005815
GO:0005886
GO:0006836
GO:0007268
GO:0007626
GO:0008021
GO:0008504
GO:0009636
GO:0009791
GO:0015311
GO:0015842
GO:0015844
GO:0015872
GO:0016020
GO:0022857
GO:0023052
GO:0030424
GO:0030425
GO:0030667
GO:0030672
GO:0031410
GO:0042137
GO:0042995
GO:0043195
GO:0043226
GO:0043231
GO:0045202
GO:0051610
GO:0051615
GO:0055085
GO:0070083
GO:0098691
GO:0098700
GO:0099123
GO:1902600
GO:1903427
HMNXSV003054807
Hs.1813.0.S2_3p_at
Hs2.1813.1.S1_3p_s_at
ILMN_2070003
L14269_at
TC10000850.hg
Participates
as a member of
VMAT1/2 [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
as a component of
Dopamine loaded synaptic vesicle [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
Noradrenalin loaded synaptic vesicle [clathrin-coated endocytic vesicle] (Homo sapiens)
Serotonin loaded synaptic vesicle [clathrin-sculpted monoamine transport vesicle membrane] (Homo sapiens)
Other forms of this molecule
SLC18A2 [plasma membrane]
Inferred To
cat-1 [clathrin-sculpted monoamine transport vesicle membrane]
(Caenorhabditis elegans)
Slc18a2 [clathrin-sculpted monoamine transport vesicle membrane]
(Mus musculus)
Slc18a2 [clathrin-sculpted monoamine transport vesicle membrane]
(Rattus norvegicus)
prt [clathrin-sculpted monoamine transport vesicle membrane]
(Drosophila melanogaster)
LOC101732756 [clathrin-sculpted monoamine transport vesicle membrane]
(Xenopus tropicalis)
Ghost homologue of SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane]
(Danio rerio)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane]
(Bos taurus)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane]
(Canis familiaris)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane]
(Gallus gallus)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane]
(Schizosaccharomyces pombe)
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane]
(Sus scrofa)
Vmat [clathrin-sculpted monoamine transport vesicle membrane]
(Drosophila melanogaster)
Homologues of SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_003045.2
Guide to Pharmacology - Targets
1012
OpenTargets
ENSG00000165646
ENSEMBL
ENST00000644641
,
ENSP00000496339
ZINC - Substances
VMAT2_HUMAN
ZINC - Biogenic
VMAT2_HUMAN
ZINC target
Q05940
PRO
Q05940
GlyGen
Q05940
PDB
8WLL
,
8JTA
,
8JSX
,
8WLJ
,
8JT9
,
8T69
,
8JSW
,
8WLK
,
8XOB
,
8T6A
,
8JT5
,
8THR
,
8XOA
,
8T6B
,
8XO9
,
8JTC
,
8WLM
,
8JTB
HPA
ENSG00000165646-SLC18A2
Pharos - Targets
Q05940
Orphanet
SLC18A2
ZINC - Predictions - Purchasable
VMAT2_HUMAN
HMDB Protein
HMDBP02489
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P25025 CXCR2
2
CXCR2 [plasma membrane]
(R-HSA-373796)
CXCR2 [secretory granule membrane]
(R-HSA-6804771)
0.556
3
UniProt:P30825 SLC7A1
1
SLC7A1 [plasma membrane]
(R-HSA-375771)
0.556
3
UniProt:Q8TDV0 GP151
0.556
3
UniProt:Q9BXR6 CFHR5
1
CFHR5 [extracellular region]
(R-HSA-8851419)
0.556
3
UniProt:Q16617 NKG7
0.556
3
UniProt:Q6N075 MFSD5
0.556
3
UniProt:Q6PL45-2 BRICD5
0.556
3
UniProt:Q96B49 TOMM6
1
TOMM6 [mitochondrial outer membrane]
(R-HSA-1252171)
0.556
3
UniProt:Q9BVC6 TM109
0.556
3
UniProt:Q96DZ9-2 CMTM5
0.556
3
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