FarC-PTP4A2 binds RABGGTB

Stable Identifier
R-HSA-8870457
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PTP4A2, also known as PRL2, is a member of the protein tyrosine phosphatase family. Farnesylated PTP4A2 interacts with RABGGTB, one of the two catalytic subunits of the RAB geranylgeranyl transferase complex and prevents its association with the other catalytic subunit RABGBTA (Si et al, 2001). In this way, binding of PTP4A2 acts as a negative regulator of RAB geranylgeranylation (reviewed in Gutkowska and Swiezewska, 2012).

Literature References
PubMed ID Title Journal Year
11447212 Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II

Si, X, Zeng, Q, Ng, CH, Hong, W, Pallen, CJ

J. Biol. Chem. 2001
22694141 Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein

Gutkowska, M, Swiezewska, E

Mol. Membr. Biol. 2012
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