PTP4A2, also known as PRL2, is a member of the protein tyrosine phosphatase family. Farnesylated PTP4A2 interacts with RABGGTB, one of the two catalytic subunits of the RAB geranylgeranyl transferase complex and prevents its association with the other catalytic subunit RABGBTA (Si et al, 2001). In this way, binding of PTP4A2 acts as a negative regulator of RAB geranylgeranylation (reviewed in Gutkowska and Swiezewska, 2012).
