Reactome | FarC-PTP4A2 binds RABGGTB

FarC-PTP4A2 binds RABGGTB

Stable Identifier

R-HSA-8870457

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PTP4A2, also known as PRL2, is a member of the protein tyrosine phosphatase family. Farnesylated PTP4A2 interacts with RABGGTB, one of the two catalytic subunits of the RAB geranylgeranyl transferase complex and prevents its association with the other catalytic subunit RABGBTA (Si et al, 2001). In this way, binding of PTP4A2 acts as a negative regulator of RAB geranylgeranylation (reviewed in Gutkowska and Swiezewska, 2012).

Literature References

PubMed ID	Title	Journal	Year
22694141	Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein Swiezewska, E, Gutkowska, M	Mol. Membr. Biol.	2012
11447212	Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II Hong, W, Si, X, Ng, CH, Pallen, CJ, Zeng, Q	J. Biol. Chem.	2001