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KLHL42 [cytosol]
Stable Identifier
R-HSA-8863204
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Kelch-like protein 42, KLH42_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL42 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9P2K6 KLHL42
Gene Names
KLHL42, KIAA1340, KLHDC5
Chain
chain:1-505
Reference Genes
BioGPS Gene:57542 KLHL42
CTD Gene:57542 KLHL42
dbSNP Gene:57542 KLHL42
ENSEMBL:ENSG00000087448 KLHL42
ENSEMBL_homo_sapiens_GENE:ENSG00000087448 KLHL42
HGNC:29252 KLHL42
KEGG Gene (Homo sapiens):57542 KLHL42
Monarch:57542 KLHL42
NCBI Gene:57542 KLHL42
UCSC:Q9P2K6 KLHL42
Reference Transcript
RefSeq:NM_020782.1 KLHL42
Other Identifiers
0000780025
11721052_at
11721053_s_at
11721054_at
11756775_a_at
16749524
20979
225732_at
225961_at
225963_at
3409366
3409367
3409368
3409369
3409370
3409371
3409375
3409383
3409384
3409385
53026_at
54964_at
57542
76214_at
7954604
A_23_P13679
A_24_P304485
A_24_P645765
A_24_P940576
AAH28742
AAI08670
AAI37117
AAI37118
B2RNT7
BAA92578
BAG53048
CCDS31763
EAW96571
ENSG00000087448
ENSP00000370671
ENST00000381271
EntrezGene:57542
F5H523
GE53916
GE56042
GO:0000209
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005819
GO:0005829
GO:0005856
GO:0006464
GO:0007049
GO:0008150
GO:0009056
GO:0016567
GO:0031463
GO:0032886
GO:0032991
GO:0043161
GO:0043226
GO:0043687
GO:0051301
HGNC:29252
HPA020979
Hs.284270.0.S1_3p_at
Hs.51743.0.S1_3p_at
Hs.51743.0.S2_3p_at
ILMN_1727134
IPR000210
IPR006652
IPR011333
IPR011705
IPR015915
KLHL42
KLHL42-201
NM_020782
NP_065833
PF01344
PF07707
PH_hs_0023471
SM00612
TC12000272.hg
uc001rij.4
UPI0000185FB1
Participant Of
hasMember
BTB proteins [cytosol]
Inferred To
Homologues of KLHL42 [cytosol] (Sus scrofa)
KLHL42 [cytosol] (Bos taurus)
KLHL42 [cytosol] (Canis familiaris)
KLHL42 [cytosol] (Danio rerio)
KLHL42 [cytosol] (Gallus gallus)
KLHL42 [cytosol] (Mus musculus)
KLHL42 [cytosol] (Rattus norvegicus)
KLHL42 [cytosol] (Sus scrofa)
KLHL42 [cytosol] (Taeniopygia guttata)
KLHL42 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_065833.1
OpenTargets
ENSG00000087448
GeneCards
Q9P2K6
PRO
Q9P2K6
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07237 P4HB
3
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
0.488
2
UniProt:P01189 POMC
12
POMC(138-150) [extracellular region]
(R-HSA-388593)
POMC(138-176) [extracellular region]
(R-HSA-388607)
POMC(217-234) [extracellular region]
(R-HSA-388617)
POMC(77-87) [extracellular region]
(R-HSA-388618)
POMC(237-241) [extracellular region]
(R-HSA-167407)
POMC(237-267) [extracellular region]
(R-HSA-167405)
POMC(138-176) [cytosol]
(R-HSA-1502544)
POMC(138-176) K25* [extracellular region]
(R-HSA-5623536)
POMC(138-176) E79* [extracellular region]
(R-HSA-5623539)
POMC(138-176) R236G [extracellular region]
(R-HSA-5603387)
POMC(1-241) [secretory granule lumen]
(R-HSA-378943)
POMC(138-176) [secretory granule lumen]
(R-HSA-378965)
0.488
2
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