Reactome | KLHL42 [cytosol]

KLHL42 [cytosol]

Stable Identifier

R-HSA-8863204

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Kelch-like protein 42, KLH42_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
      - Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
      - Polyubiquitination of substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
      - Release of E3 from polyubiquitinated substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
      - Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        KLHL42 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9P2K6 KLHL42

Gene Names

KLHL42, KIAA1340, KLHDC5

Chain

chain:1-505

Reference Genes

BioGPS Gene:57542 KLHL42

COSMIC (genes):KLHL42 KLHL42

CTD Gene:57542 KLHL42

dbSNP Gene:57542 KLHL42

ENSEMBL:ENSG00000087448 KLHL42

ENSEMBL_homo_sapiens_GENE:ENSG00000087448.11 KLHL42

HGNC:29252 KLHL42

KEGG Gene (Homo sapiens):57542 KLHL42

Monarch:57542 KLHL42

NCBI Gene:57542 KLHL42

OMIM:618919 KLHL42

UCSC:Q9P2K6 KLHL42

Reference Transcript

RefSeq:NM_020782.1 KLHL42

Other Identifiers

11721052_at

11721053_s_at

11721054_at

11756775_a_at

225732_PM_at

225732_at

225961_PM_at

225961_at

225963_PM_at

225963_at

3409366

3409367

3409368

3409369

3409370

3409371

3409375

3409383

3409384

3409385

53026_at

54964_at

57542

76214_at

7954604

A_23_P13679

A_24_P304485

A_24_P645765

A_24_P940576

GE53916

GE56042

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0007049

GO:0016567

GO:0016740

GO:0030163

GO:0031463

GO:0032886

GO:0036211

GO:0043161

GO:0043226

GO:0051301

GO:0140096

HMNXSV003031814

Hs.284270.0.S1_3p_at

Hs.51743.0.S1_3p_at

Hs.51743.0.S2_3p_at

ILMN_1727134

PH_hs_0023471

TC12000272.hg

Participates

as a member of

BTB proteins [cytosol] (Homo sapiens)

Inferred To

Klhl42 [cytosol] (Mus musculus)

KLHL42 [cytosol] (Bos taurus)

KLHL42 [cytosol] (Canis familiaris)

KLHL42 [cytosol] (Dictyostelium discoideum)

KLHL42 [cytosol] (Gallus gallus)

KLHL42 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_065833.1

OpenTargets

ENSG00000087448

GeneCards

Q9P2K6

HPA

ENSG00000087448-KLHL42

Ensembl

ENST00000381271, ENSP00000370671, ENSG00000087448

PRO

Q9P2K6

Pharos - Targets

Q9P2K6

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01189 POMC	12	POMC(138-176) [secretory granule lumen] (R-HSA-378965) POMC(1-241) [secretory granule lumen] (R-HSA-378943) POMC(138-176) R236G [extracellular region] (R-HSA-5603387) POMC(138-176) E79* [extracellular region] (R-HSA-5623539) POMC(138-176) K25* [extracellular region] (R-HSA-5623536) POMC(138-176) [cytosol] (R-HSA-1502544) POMC(77-87) [extracellular region] (R-HSA-388618) POMC(217-234) [extracellular region] (R-HSA-388617) POMC(138-150) [extracellular region] (R-HSA-388593) POMC(138-176) [extracellular region] (R-HSA-388607) POMC(237-267) [extracellular region] (R-HSA-167405) POMC(237-241) [extracellular region] (R-HSA-167407)	0.556	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.527	2
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.527	2
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.527	2
UniProt:Q9HC36 MRM3	1	RNMTL1 [mitochondrial matrix] (R-HSA-6793067)	0.527	2
UniProt:P61081 UBE2M	5	AcM-UBE2M [nucleoplasm] (R-HSA-8952502) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) UBE2M [cytosol] (R-HSA-947619) AcM-UBE2M [cytosol] (R-HSA-8951627) G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894)	0.527	2

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