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G76-NEDD8-C111-AcM-UBE2M [cytosol]
Stable Identifier
R-HSA-4419894
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
NIK-->noncanonical NF-kB signaling (Homo sapiens)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Homo sapiens)
NEDD8-AcM-UBE2M:CUL9:RBX1 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CUL9:RBX1 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
Transfer of NEDD8 to AcM-UBE2M (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
CBL neddylates TGFBR2 (Homo sapiens)
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
G76-NEDD8-C111-AcM-UBE2M [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61081 UBE2M
Gene Names
UBE2M, UBC12
Chain
chain:1-183
Reference Genes
BioGPS Gene:9040 UBE2M
COSMIC (genes):UBE2M UBE2M
CTD Gene:9040 UBE2M
dbSNP Gene:9040 UBE2M
ENSEMBL:ENSG00000130725 UBE2M
ENSEMBL_homo_sapiens_GENE:ENSG00000130725.8 UBE2M
HGNC:12491 UBE2M
KEGG Gene (Homo sapiens):9040 UBE2M
Monarch:9040 UBE2M
NCBI Gene:9040 UBE2M
OMIM:603173 UBE2M
UCSC:P61081 UBE2M
Reference Transcript
RefSeq:NM_003969.3 UBE2M
Other Identifiers
11722192_s_at
16876191
203109_PM_at
203109_at
33781_s_at
33782_r_at
3689612
3689615
3689616
3689617
3689618
3873000
3873001
3873002
3873004
3873006
3873007
3873009
3873011
3873012
3873013
3873014
3873015
8039805
9040
A_23_P141847
GE79231
GO:0000166
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005829
GO:0012501
GO:0016740
GO:0019787
GO:0019788
GO:0032446
GO:0036211
GO:0043226
GO:0043525
GO:0043687
GO:0045116
GO:0061654
GO:0140096
ILMN_1701331
PH_hs_0030050
TC19001923.hg
g4507790_3p_at
Participates
as an output of
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
as an input of
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
as a component of
NEDD8-AcM-UBE2M [cytosol] (Homo sapiens)
Other forms of this molecule
AcM-UBE2M [nucleoplasm]
G76-NEDD8-C111-AcM-UBE2M [nucleoplasm]
UBE2M [cytosol]
AcM-UBE2M [cytosol]
Inferred To
G76-NEDD8-C111-AcM-UBE2M [cytosol]
(Gallus gallus)
G76-NEDD8-C111-AcM-UBE2M [cytosol]
(Plasmodium falciparum)
ubc12 [cytosol]
(Schizosaccharomyces pombe)
ube2m [cytosol]
(Dictyostelium discoideum)
ube2m [cytosol]
(Xenopus tropicalis)
Ghost homologue of G76-NEDD8-C111-AcM-UBE2M [cytosol]
(Caenorhabditis elegans)
Ghost homologue of G76-NEDD8-C111-AcM-UBE2M [cytosol]
(Danio rerio)
UbcE2M [cytosol]
(Drosophila melanogaster)
UBC12 [cytosol]
(Saccharomyces cerevisiae)
UBE2M [cytosol]
(Bos taurus)
UBE2M [cytosol]
(Canis familiaris)
UBE2M [cytosol]
(Sus scrofa)
Ube2m [cytosol]
(Mus musculus)
Ube2m [cytosol]
(Rattus norvegicus)
Modified Residues
Name
Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 111 and 76
Coordinate
111
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Name
N-acetyl-L-methionine at 1
Coordinate
1
PsiMod Name
N-acetyl-L-methionine [MOD:00058]
PsiMod Definition
A protein modification that effectively converts an L-methionine to N-acetyl-L-methionine.
Cross References
RefSeq
NP_003960.1
OpenTargets
ENSG00000130725
HPA
ENSG00000130725-UBE2M
GeneCards
P61081
Ensembl
ENSP00000253023
,
ENST00000253023
,
ENSG00000130725
PRO
P61081
Pharos - Targets
P61081
HMDB Protein
HMDBP00563
PDB
3TDZ
,
4GAO
,
4P5O
,
3TDU
,
2NVU
,
1Y8X
,
1TT5
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8 [cytosol]
(R-HSA-416969)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
0.936
11
UniProt:Q8TBC4 UBA3
2
UBA3 [cytosol]
(R-HSA-947632)
G76-NEDD8-C237-UBA3 [cytosol]
(R-HSA-8951640)
0.825
5
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.786
5
UniProt:P62877 RBX1
2
RBX1 [nucleoplasm]
(R-HSA-1234142)
RBX1 [cytosol]
(R-HSA-180582)
0.754
7
UniProt:Q96GG9 DCUN1D1
2
DCUN1D1 [nucleoplasm]
(R-HSA-8952487)
DCUN1D1 [cytosol]
(R-HSA-8951781)
0.744
5
UniProt:Q13564 NAE1
1
NAE1 [cytosol]
(R-HSA-8951449)
0.744
4
UniProt:Q7L5N1 COPS6
2
COPS6 [nucleoplasm]
(R-HSA-5697026)
COPS6 [cytosol]
(R-HSA-416961)
0.643
3
UniProt:O60260-5 PRKN
0.556
3
UniProt:P62879 GNB2
4
GNB2 [cytosol]
(R-HSA-6814421)
Partially folded GNB2 [cytosol]
(R-HSA-8850536)
Unfolded GNB2 [cytosol]
(R-HSA-6814202)
GNB2 [plasma membrane]
(R-HSA-164335)
0.556
3
UniProt:Q9P2K6 KLHL42
1
KLHL42 [cytosol]
(R-HSA-8863204)
0.527
2
UniProt:Q9UBW8 COPS7A
2
COPS7A [nucleoplasm]
(R-HSA-5697011)
COPS7A [cytosol]
(R-HSA-416964)
0.527
2
UniProt:Q8TBC3 SHKBP1
1
SHKBP1 [cytosol]
(R-HSA-9714849)
0.527
2
UniProt:Q8WVZ9 KBTBD7
1
KBTBD7 [cytosol]
(R-HSA-5658415)
0.527
2
UniProt:Q9H9Q2 COPS7B
2
COPS7B [cytosol]
(R-HSA-416966)
COPS7B [nucleoplasm]
(R-HSA-5697023)
0.527
2
UniProt:Q9BT78 COPS4
2
COPS4 [nucleoplasm]
(R-HSA-5697020)
COPS4 [cytosol]
(R-HSA-416965)
0.527
2
UniProt:Q9Y2I1 NISCH
1
NISCH [cytosol]
(R-HSA-9691384)
0.527
2
UniProt:Q9H0C5 BTBD1
1
BTBD1 [cytosol]
(R-HSA-8851650)
0.527
2
UniProt:Q86V97 KBTBD6
1
KBTBD6 [cytosol]
(R-HSA-8863221)
0.527
2
UniProt:Q92905 COPS5
2
COPS5 [nucleoplasm]
(R-HSA-5697019)
COPS5 [cytosol]
(R-HSA-416963)
0.527
2
UniProt:O94844 RHOBTB1
1
RHOBTB1 [endosome membrane]
(R-HSA-194899)
0.527
2
UniProt:Q8NC69 KCTD6
1
KCTD6 [cytosol]
(R-HSA-8863321)
0.527
2
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