Reactome | KLHL42 [cytosol]

KLHL42 [cytosol]

Stable Identifier

R-BTA-8863204

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

cytosol

Synonyms

KLHL42, F1MFH5

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - Class I MHC mediated antigen processing & presentation (Bos taurus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Bos taurus)
      - Interaction of E3 with substrate and E2-Ub complex (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
      - Polyubiquitination of substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
      - Release of E3 from polyubiquitinated substrate (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
      - Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
        
        E3:Ub:substrate [cytosol] (Bos taurus)
        
        E3 ligases in proteasomal degradation [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)

Metabolism of proteins (Bos taurus)

- Post-translational protein modification (Bos taurus)
  - Neddylation (Bos taurus)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Bos taurus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Bos taurus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Bos taurus)
        
        CRL E3 ubiquitin ligases [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Bos taurus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Bos taurus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Bos taurus)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Bos taurus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Bos taurus)
        
        RBX1:CUL3:BTB [cytosol] (Bos taurus)
        
        BTB proteins [cytosol] (Bos taurus)
        
        KLHL42 [cytosol] (Bos taurus)

External Reference Information

External Reference

UniProt:F1MFH5

Gene Names

KLHL42

Reference Genes

BioGPS Gene:781458 KLHL42

ENSEMBL:ENSBTAG00000006372.4

KEGG Gene (Bos taurus):781458 KLHL42

Monarch:781458 KLHL42

NCBI Gene:781458 KLHL42

Reference Transcript

RefSeq:NM_001205415.1 KLHL42

Other Identifiers

781458

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0016740

GO:0030163

GO:0031463

GO:0032886

GO:0036211

GO:0043161

GO:0140096

Participates

as a member of

BTB proteins [cytosol] (Bos taurus)

Inferred From

KLHL42 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001192344.1

OpenTargets

ENSG00000087448

Ensembl

ENSBTAT00000008359, ENSBTAG00000006372, ENSBTAP00000008359

VGNC

30667

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