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POMC(138-150) [extracellular region]
Stable Identifier
R-HSA-388593
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Melanocyte-stimulating hormone alpha, alpha-MSH, RecName: Full=Corticotropin-lipotropin; AltName: Full=Pro-opiomelanocortin; Short=POMC; Contains: RecName: Full=NPP; Contains: RecName: Full=Melanotropin gamma; AltName: Full=Gamma-MSH; Contains: RecName: Full=Potential peptide; Contains: RecName: Full=Corticotropin; AltName: Full=Adrenocorticotropic hormone; Short=ACTH; Contains: RecName: Full=Melanotropin alpha; AltName: Full=Alpha-MSH; Contains: RecName: Full=Corticotropin-like intermediary peptide; Short=CLIP; Contains: RecName: Full=Lipotropin beta; AltName: Full=Beta-LPH; Contains: RecName: Full=Lipotropin gamma; AltName: Full=Gamma-LPH; Contains: RecName: Full=Melanotropin beta; AltName: Full=Beta-MSH; Contains: RecName: Full=Beta-endorphin; Contains: RecName: Full=Met-enkephalin; Flags: Precursor;
GN Name=POMC;
OS Homo sapiens, COLI_HUMAN, POMC
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
POMC gene expression is inhibited by FOXO1 (Homo sapiens)
POMC(138-150) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
MSH [extracellular region] (Homo sapiens)
POMC(138-150) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
MSH [extracellular region] (Homo sapiens)
POMC(138-150) [extracellular region] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
MSH [extracellular region] (Homo sapiens)
POMC(138-150) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
MSH [extracellular region] (Homo sapiens)
POMC(138-150) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
MSH [extracellular region] (Homo sapiens)
POMC(138-150) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
MSH [extracellular region] (Homo sapiens)
POMC(138-150) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Melanocortin receptors bind melanocortins (Homo sapiens)
MSH [extracellular region] (Homo sapiens)
POMC(138-150) [extracellular region] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
MSH [extracellular region] (Homo sapiens)
POMC(138-150) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01189 POMC
Gene Names
POMC
Chain
signal peptide:1-26, peptide:27-102, peptide:77-87, peptide:105-134, peptide:138-176, peptide:138-150, peptide:156-176, peptide:179-267, peptide:179-234, peptide:217-234, peptide:237-267, peptide:237-241
Reference Genes
BioGPS Gene:5443 POMC
COSMIC (genes):POMC POMC
CTD Gene:5443 POMC
dbSNP Gene:5443 POMC
ENSEMBL:ENSG00000115138 POMC
ENSEMBL_homo_sapiens_GENE:ENSG00000115138 POMC
HGNC:9201 POMC
KEGG Gene (Homo sapiens):5443 POMC
Monarch:5443 POMC
NCBI Gene:5443 POMC
OMIM:176830 POMC
UCSC:P01189 POMC
Reference Transcript
RefSeq:NM_000939.3 POMC
RefSeq:NM_001319204.1 POMC
RefSeq:NM_001035256.2 POMC
RefSeq:NM_001319205.1 POMC
Other Identifiers
0006420112
11716427_a_at
16895337
205720_at
2544631
2544632
2544633
2544634
2544635
2544636
2544637
2544638
2544639
2544640
2544641
2544643
2544644
2762
33711_at
4126575
46135
4XNH
4XPD
4Y49
5443
63644
8050805
A_23_P5875
A_33_P3345036
AAA35799
AAA60140
AAB59621
AAH65832
AAY24354
AC012457
BC065832
CAA24754
CAB002762
CCDS1717
CH471053
E9PHK5
EAX00729
EAX00730
ENSG00000115138
ENSP00000264708
ENSP00000370171
ENSP00000379170
ENSP00000384092
ENST00000264708
ENST00000380794
ENST00000395826
ENST00000405623
EntrezGene:5443
g4505948_3p_at
GE61306
GO:0001664
GO:0003013
GO:0003674
GO:0005102
GO:0005179
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005737
GO:0005975
GO:0006091
GO:0006810
GO:0007165
GO:0007186
GO:0007218
GO:0007267
GO:0008150
GO:0008217
GO:0009058
GO:0010469
GO:0019221
GO:0030141
GO:0031410
GO:0031781
GO:0031782
GO:0032098
GO:0032720
GO:0033059
GO:0034641
GO:0034774
GO:0042592
GO:0042593
GO:0043226
GO:0043473
GO:0044281
GO:0045944
GO:0070873
GO:0070996
GO:2000852
HGNC:9201
HPA046135
HPA063644
ILMN_1672899
ILMN_2403664
IPR001941
IPR013531
IPR013532
IPR013593
J00291
J00292
M25896
M38297
MIM:176830
MIM:601665
MIM:609734
NM_000939
NM_001035256
NM_001319204
NM_001319205
NP_000930
NP_001030333
NP_001306133
NP_001306134
PF00976
PF08035
PF08384
PH_hs_0000252
POMC
POMC-201
POMC-202
POMC-203
POMC-204
PR00383
SM01363
SM01364
SM01365
TC02001657.hg
TC02004119.hg
uc002rfy.1
uc002rfz.2
uc002rga.2
uc061heu.1
UPI0000127E5B
V01510
V01510_rna1_at
Participant Of
hasMember
MSH [extracellular region]
output
POMC gene expression is inhibited by FOXO1
Other forms of this molecule
POMC(138-176) [extracellular region]
POMC(217-234) [extracellular region]
POMC(77-87) [extracellular region]
POMC(237-241) [extracellular region]
POMC(237-267) [extracellular region]
POMC(138-176) [cytosol]
POMC(138-176) K25* [extracellular region]
POMC(138-176) E79* [extracellular region]
POMC(138-176) R236G [extracellular region]
POMC(1-241) [secretory granule lumen]
POMC(138-176) [secretory granule lumen]
Inferred To
POMC(138-150) [extracellular region] (Bos taurus)
POMC(138-150) [extracellular region] (Canis familiaris)
POMC(138-150) [extracellular region] (Danio rerio)
POMC(138-150) [extracellular region] (Gallus gallus)
POMC(138-150) [extracellular region] (Mus musculus)
POMC(138-150) [extracellular region] (Rattus norvegicus)
POMC(138-150) [extracellular region] (Sus scrofa)
POMC(138-150) [extracellular region] (Taeniopygia guttata)
POMC(138-150) [extracellular region] (Xenopus tropicalis)
Homologues of POMC(138-150) [extracellular region] (Danio rerio)
Homologues of POMC(138-150) [extracellular region] (Sus scrofa)
Cross References
RefSeq
NP_001306134.1
,
NP_001030333.1
,
NP_000930.1
,
NP_001306133.1
OpenTargets
ENSG00000115138
GeneCards
P01189
DOCK Blaster
4XNH
,
4XPD
,
4Y49
PRO
P01189
Orphanet
16448
PDB
4Y49
,
4XPD
,
4XNH
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9P2K6 KLHL42
1
KLHL42 [cytosol]
(R-HSA-8863204)
0.488
2
UniProt:Q9NX04 CA109
0.488
2
UniProt:O75031 HSF2B
0.488
4
UniProt:Q9UMX2-2 OAZ3
0.488
2
UniProt:Q8NI38 IKBD
0.488
2
UniProt:Q13064 MKRN3
0.488
2
UniProt:Q8N8Y2 ATP6V0D2
2
ATP6V0D2 [endosome membrane]
(R-HSA-912599)
ATP6V0D2 [phagocytic vesicle membrane]
(R-HSA-1222586)
0.488
2
UniProt:Q99757 TXN2
3
HC-TXN2 [mitochondrial matrix]
(R-HSA-9035482)
TXN2 [mitochondrial matrix]
(R-HSA-3323048)
2xHC-TXN2 [mitochondrial matrix]
(R-HSA-3323059)
0.488
2
UniProt:Q7Z4H3 HDDC2
0.488
2
UniProt:P51687 SUOX
1
SUOX [mitochondrial matrix]
(R-HSA-1614570)
0.488
2
UniProt:Q68D86 C102B
0.488
2
UniProt:P62508-3 ESRRG
0.488
2
UniProt:Q7RTU4 BHA09
0.488
2
UniProt:Q96HA8 NTAQ1
0.488
2
UniProt:Q8IVS8 GLYCTK
1
GLYCTK [cytosol]
(R-HSA-6799244)
0.488
2
UniProt:Q9NYB9-2 ABI2
0.488
2
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