Reactome | POMC(138-150) [extracellular region]

POMC(138-150) [extracellular region]

Stable Identifier

R-HSA-388593

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Melanocyte-stimulating hormone alpha, alpha-MSH, RecName: Full=Corticotropin-lipotropin; AltName: Full=Pro-opiomelanocortin; Short=POMC; Contains: RecName: Full=NPP; Contains: RecName: Full=Melanotropin gamma; AltName: Full=Gamma-MSH; Contains: RecName: Full=Potential peptide; Contains: RecName: Full=Corticotropin; AltName: Full=Adrenocorticotropic hormone; Short=ACTH; Contains: RecName: Full=Melanotropin alpha; AltName: Full=Alpha-MSH; Contains: RecName: Full=Corticotropin-like intermediary peptide; Short=CLIP; Contains: RecName: Full=Lipotropin beta; AltName: Full=Beta-LPH; Contains: RecName: Full=Lipotropin gamma; AltName: Full=Gamma-LPH; Contains: RecName: Full=Melanotropin beta; AltName: Full=Beta-MSH; Contains: RecName: Full=Beta-endorphin; Contains: RecName: Full=Met-enkephalin; Flags: Precursor;
GN Name=POMC;
OS Homo sapiens, COLI_HUMAN, POMC

Icon

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Leishmania infection (Homo sapiens)
    - Leishmania parasite growth and survival (Homo sapiens)
      - Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MSH [extracellular region] (Homo sapiens)
        
        POMC(138-150) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01189 POMC

Gene Names

POMC

Chain

signal peptide:1-26, peptide:27-102, peptide:77-87, peptide:105-134, peptide:138-176, peptide:138-150, peptide:156-176, peptide:179-267, peptide:179-234, peptide:217-234, peptide:237-267, peptide:237-241

Reference Genes

BioGPS Gene:5443 POMC

COSMIC (genes):POMC POMC

CTD Gene:5443 POMC

dbSNP Gene:5443 POMC

ENSEMBL:ENSG00000115138 POMC

HGNC:9201 POMC

KEGG Gene (Homo sapiens):5443 POMC

Monarch:5443 POMC

NCBI Gene:5443 POMC

OMIM:176830 POMC

UCSC:P01189 POMC

Reference Transcript

Other Identifiers

0006420112

11716427_a_at

16895337

205720_PM_at

205720_at

2544631

2544632

2544633

2544634

2544635

2544636

2544637

2544638

2544639

2544640

2544641

2544643

2544644

2544647

33711_at

4126575

5443

8050805

A_23_P5875

A_33_P3345036

GE61306

GO:0001664

GO:0003013

GO:0003674

GO:0005102

GO:0005179

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005975

GO:0006091

GO:0006810

GO:0007165

GO:0007218

GO:0007267

GO:0008150

GO:0008217

GO:0009058

GO:0019722

GO:0030141

GO:0031410

GO:0031781

GO:0031782

GO:0032098

GO:0032720

GO:0033059

GO:0034641

GO:0034774

GO:0042592

GO:0042593

GO:0043226

GO:0043473

GO:0043950

GO:0044281

GO:0045944

GO:0070873

GO:0070996

GO:0140668

GO:1990680

GO:2000852

HMNXSV003041514

ILMN_1672899

ILMN_2403664

PH_hs_0000252

TC02001657.hg

TC02004119.hg

V01510_rna1_at

g4505948_3p_at

Participates

as an output of

POMC gene expression is inhibited by FOXO1 (Homo sapiens)

as a member of

MSH [extracellular region] (Homo sapiens)

Other forms of this molecule

POMC(138-176) [secretory granule lumen]

POMC(1-241) [secretory granule lumen]

POMC(138-176) R236G [extracellular region]

POMC(138-176) E79* [extracellular region]

POMC(138-176) K25* [extracellular region]

POMC(237-241) [extracellular region]

POMC(237-267) [extracellular region]

POMC(138-176) [extracellular region]

POMC(217-234) [extracellular region]

POMC(77-87) [extracellular region]

POMC(138-176) [cytosol]

Inferred To

Pomc [extracellular region] (Mus musculus)

Pomc [extracellular region] (Rattus norvegicus)

pomca [extracellular region] (Danio rerio)

pomc [extracellular region] (Xenopus tropicalis)

POMC [extracellular region] (Bos taurus)

POMC [extracellular region] (Canis familiaris)

POMC [extracellular region] (Gallus gallus)

POMC [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_001306133.1, NP_001306134.1, NP_001030333.1, NP_000930.1

OpenTargets

ENSG00000115138

HPA

ENSG00000115138-POMC

GeneCards

P01189

Ensembl

ENSP00000379170, ENST00000380794, ENST00000405623, ENSP00000370171, ENST00000264708, ENST00000395826, ENSG00000115138, ENSP00000264708, ENSP00000384092

PRO

P01189

Pharos - Targets

P01189

Orphanet

16448

PDB

6TUB, 4XNH, 4Y49, 4XPD

HMDB Protein

HMDBP12759

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9P2K6 KLHL42	1	KLHL42 [cytosol] (R-HSA-8863204)	0.556	3
UniProt:Q9NX04 CA109			0.556	3
UniProt:O75031 HSF2B			0.556	6
UniProt:Q8NI38 IKBD			0.556	3
UniProt:Q9UMX2-2 OAZ3			0.556	3
UniProt:Q8N8Y2 ATP6V0D2	3	ATP6V0D2 [lysosomal membrane] (R-HSA-9640179) ATP6V0D2 [phagocytic vesicle membrane] (R-HSA-1222586) ATP6V0D2 [endosome membrane] (R-HSA-912599)	0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q7Z4H3 HDDC2			0.556	3
UniProt:Q68D86 C102B			0.556	3
UniProt:P51687 SUOX	1	SUOX [mitochondrial matrix] (R-HSA-1614570)	0.556	3
UniProt:P62508-3 ESRRG			0.556	3
UniProt:Q7RTU4 BHA09			0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q9NYB9-2 ABI2			0.556	3
UniProt:Q8IVS8 GLYCTK	1	GLYCTK [cytosol] (R-HSA-6799244)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3

Cite Us!