Reactome | LOC112447880 [extracellular region]

LOC112447880 [extracellular region]

Stable Identifier

R-BTA-877351-2

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

extracellular region

Synonyms

IFNB1, A0A3Q1LZ20

Locations in the PathwayBrowser

Expand all

Immune System (Bos taurus)

- Cytokine Signaling in Immune system (Bos taurus)
  - Interferon Signaling (Bos taurus)
    - Interferon alpha/beta signaling (Bos taurus)
      - Activation of JAK kinases (Bos taurus)
        
        IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Bos taurus)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
        
        p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
      - Formation of p-STAT1 homodimer (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
      - IFN alpha/beta binds to IFNAR2 (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
      - Phosphorylation of INFAR1 by TYK2 (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
      - Phosphorylation of STAT2 (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
      - Recruitment of IFNAR1 (Bos taurus)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
        
        IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Bos taurus)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
      - Recruitment of STAT2 to p-IFNAR1 (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
      - Regulation of IFNA/IFNB signaling (Bos taurus)
        
        Dephosphorylation of JAK1 by SHP1 (Bos taurus)
        
        IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Bos taurus)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
        
        Dephosphorylation of STAT1 by SHP2 (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:STAT1 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
        
        Dephosphorylation of TYK2 by PTP1B (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
      - Release of p-STAT2:p-STAT1 dimer (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Bos taurus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Bos taurus)
        
        Homologues of IFNB1 [extracellular region] (Bos taurus)
        
        LOC112447880 [extracellular region] (Bos taurus)

External Reference Information

External Reference

UniProt:A0A3Q1LZ20

Gene Names

LOC112447880

Reference Genes

BioGPS Gene:112447880 LOC112447880

ENSEMBL:ENSBTAG00000051622.1

KEGG:bta:112447880 LOC112447880

Monarch:112447880 LOC112447880

NCBI Gene:112447880 LOC112447880

UCSC:A0A3Q1LZ20 LOC112447880

Reference Transcript

RefSeq:XM_059889379.1 LOC112447880

Other Identifiers

112447880

618946

GO:0005126

GO:0005576

GO:0006952

Participates

as a member of

Homologues of IFNB1 [extracellular region] (Bos taurus)

Inferred From

IFNB1 [extracellular region] (Homo sapiens)

Cross References

RefSeq

XP_059745362.1

ENSEMBL

ENSBTAT00000068643, ENSBTAP00000069345, ENSBTAG00000078235

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