Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
IFNAR2-2 [plasma membrane]
Stable Identifier
R-HSA-877333
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
IFNAR2c, Interferon alpha/beta receptor 2, INAR2_HUMAN, IFNAR2 isoform 2
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
Evasion by RSV of host interferon responses (Homo sapiens)
Recruitment of STAT2 to p-IFNAR1 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2:JAK1,2 inhibitors [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2:type 1 interferon analogs [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Phosphorylation of STAT1 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Activation of JAK kinases (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
Formation of p-STAT1 homodimer (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFN alpha/beta binds to IFNAR2 (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2:JAK1,2 inhibitors [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2:type 1 interferon analogs [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2:JAK1,2 inhibitors [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2:type 1 interferon analogs [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
Phosphorylation of INFAR1 by TYK2 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
Phosphorylation of STAT1 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
Phosphorylation of STAT2 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
Recruitment of IFNAR1 (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
Recruitment of STAT2 to p-IFNAR1 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
Regulation of IFNA/IFNB signaling (Homo sapiens)
Dephosphorylation of JAK1 by SHP1 (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
Dephosphorylation of STAT1 by SHP2 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:STAT1 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
Dephosphorylation of TYK2 by PTP1B (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
Inhibition of JAK kinase activity by SOCS1/3 (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
UBP43 binds IFNAR2 and prevents JAK1 interaction (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNAR2c:UBP43 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
Release of p-STAT2:p-STAT1 dimer (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2-2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48551-2 IFNAR2
Gene Names
IFNAR2, IFNABR, IFNARB
Other Identifiers
11724685_x_at
11724686_x_at
11749121_a_at
1568_s_at
1569_r_at
1588_at
1589_s_at
16922222
16922241
204785_PM_x_at
204785_x_at
204786_PM_s_at
204786_s_at
227125_PM_at
227125_at
3455
3918479
3918490
3918491
3918492
3918493
3918496
3918497
3918499
3918502
3918503
3918510
3918511
3918512
3918513
3918514
3918515
3918534
3918536
3918537
3918538
3918539
3918540
3918541
8068238
A_23_P211080
A_33_P3337540
A_33_P3361457
GE80961
GE88322
GO:0002376
GO:0004905
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0007166
GO:0007259
GO:0008269
GO:0009615
GO:0016020
GO:0019901
GO:0019955
GO:0019962
GO:0023052
GO:0035455
GO:0035456
GO:0035458
GO:0042018
GO:0046425
GO:0051607
GO:0060089
GO:0060090
GO:0060337
GO:0098542
GO:0098586
GO:0140865
HMNXSV003010434
HMNXSV003047000
Hs.237955.1.A1_3p_at
ILMN_1765146
ILMN_1791057
ILMN_2347999
L42243_cds1_at
PH_hs_0026732
TC21001060.hg
g4504600_3p_a_at
g4504600_3p_x_at
g995296_3p_a_at
Participates
as a component of
IFNAR2c:UBP43 [plasma membrane] (Homo sapiens)
IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
as an input of
UBP43 binds IFNAR2 and prevents JAK1 interaction (Homo sapiens)
Inferred To
Homologues of IFNAR2-2 [plasma membrane]
(Danio rerio)
Homologues of IFNAR2-2 [plasma membrane]
(Xenopus tropicalis)
Ifnar2 [plasma membrane]
(Mus musculus)
Ifnar2 [plasma membrane]
(Rattus norvegicus)
ifnlr1 [plasma membrane]
(Danio rerio)
ifnlr1 [plasma membrane]
(Xenopus tropicalis)
IFNAR2-2 [plasma membrane]
(Gallus gallus)
ifngr2 [plasma membrane]
(Danio rerio)
IFNAR2 [plasma membrane]
(Bos taurus)
IFNAR2 [plasma membrane]
(Canis familiaris)
IFNAR2 [plasma membrane]
(Sus scrofa)
ifnar2.2 [plasma membrane]
(Xenopus tropicalis)
crfb12 [plasma membrane]
(Danio rerio)
il22ra1 [plasma membrane]
(Xenopus tropicalis)
crfb4 [plasma membrane]
(Danio rerio)
il22ra2 [plasma membrane]
(Danio rerio)
il10ra [plasma membrane]
(Danio rerio)
il10ra [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001276055.1
,
NP_997467.1
,
NP_997468.1
,
NP_001276054.1
,
NP_000865.2
,
NP_001276057.1
Guide to Pharmacology - Targets
1724
OpenTargets
ENSG00000159110
GeneCards
P48551
HPA
ENSG00000159110-IFNAR2
Ensembl
ENSP00000371699
,
ENSP00000343957
,
ENSP00000343289
,
ENSP00000508013
,
ENST00000342101
,
ENST00000404220
,
ENST00000342136
,
ENSP00000384309
,
ENST00000382264
,
ENSG00000159110
,
ENST00000683941
PRO
P48551
Pharos - Targets
P48551
Orphanet
24612
PDB
3SE4
,
2LAG
,
3S8W
,
1N6V
,
2HYM
,
3S9D
,
3SE3
,
1N6U
,
2KZ1
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52630 STAT2
4
p-Y690-STAT2 [cytosol]
(R-HSA-909683)
STAT2 [cytosol]
(R-HSA-882029)
p-Y690-STAT2 [nucleoplasm]
(R-HSA-909673)
p-Y-STAT2 [cytosol]
(R-HSA-8987235)
0.688
4
UniProt:Q00978 IRF9
2
IRF9 [nucleoplasm]
(R-HSA-913522)
IRF9 [cytosol]
(R-HSA-879183)
0.623
6
UniProt:P23458 JAK1
6
p-Y1034,Y1035-JAK1 [cytosol]
(R-HSA-9005335)
JAK1 [endosome]
(R-HSA-8983168)
p-JAK1 [cytosol]
(R-HSA-8950711)
p-Y1034-JAK1 [cytosol]
(R-HSA-1112543)
JAK1 [cytosol]
(R-HSA-451898)
p-Y-JAK1 [cytosol]
(R-HSA-451921)
0.591
3
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.581
4
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.576
4
UniProt:P42224 STAT1
8
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
STAT1 [cytosol]
(R-HSA-629622)
0.499
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text