N-atom dealkylation of caffeine

Stable Identifier
R-HSA-76426
Type
Reaction [transition]
Species
Homo sapiens
Compartment
smooth endoplasmic reticulum
ReviewStatus
5/5
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N-atom dealkylation of caffeine
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Caffeine is one of the world's most frequently consumed xenobiotic. The major source of caffeine comes from tea and coffee. Caffeine is extensively metabolized in humans with at least 17 metabolites formed in its biotransformation. CYP1A2 is a prominent enzyme in the formation of an important metabolite of caffeine (paraxanthine) by N3-demethylation.
Literature References
PubMed ID Title Journal Year
8553685 Determination of P4501A2 activity in human liver microsomes using [3-14C-methyl]caffeine

Bloomer, JC, Clarke, SE, Chenery, RJ

Xenobiotica 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]

Physical Entity
CYP1A2 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
N-atom dealkylation of caffeine (Bos taurus)
N-atom dealkylation of caffeine (Danio rerio)
N-atom dealkylation of caffeine (Mus musculus)
N-atom dealkylation of caffeine (Rattus norvegicus)
N-atom dealkylation of caffeine (Sus scrofa)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2003-08-05)
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