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HNF1B [nucleoplasm]
Stable Identifier
R-HSA-3004721
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Hepatocyte nuclear factor 1-beta, HNF1B_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Developmental Cell Lineages of the Exocrine Pancreas (Homo sapiens)
Developmental Lineage of Multipotent Pancreatic Progenitor Cells (Homo sapiens)
Duodeno-pancreatic endoderm cell produces primary multipotent pancreatic progenitor cell (Homo sapiens)
primary multipotent pancreatic progenitor cell (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
Ventral foregut endoderm cell produces primary multipotent pancreatic progenitor cell (Homo sapiens)
primary multipotent pancreatic progenitor cell (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
Developmental Lineage of Pancreatic Acinar Cells (Homo sapiens)
Primary multipotent pancreatic progenitor cell produces pancreatic tip progenitor cell (Homo sapiens)
primary multipotent pancreatic progenitor cell (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
Developmental Lineage of Pancreatic Ductal Cells (Homo sapiens)
Primary multipotent pancreatic progenitor cell produces trunk bipotent pancreatic progenitor cell (Homo sapiens)
primary multipotent pancreatic progenitor cell (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
Trunk bipotent pancreatic progenitor cell produces pancreatic ductal cell (Homo sapiens)
pancreatic ductal cell (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
Kidney development (Homo sapiens)
Nephron development (Homo sapiens)
Expression of DLL1 during nephron development (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B:DLL1 gene [nucleoplasm] (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
Expression of HNF4A during nephron development (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B:HNF1A gene [nucleoplasm] (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
Expression of IRX1 during nephron development (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B:IRX1 gene [nucleoplasm] (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
Expression of IRX2 during nephron development (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B:IRX2 gene [nucleoplasm] (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
Expression of JAG1 during nephron development (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
Expression of LFNG during nephron development (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B:LFNG gene [nucleoplasm] (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
Expression of POU3F3 during nephron development (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
Expression of WNT9B during nephron development (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B:WNT9B gene [nucleoplasm] (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B binds the DLL1 gene (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B:DLL1 gene [nucleoplasm] (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B binds the HNF4A gene (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B:HNF1A gene [nucleoplasm] (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B binds the IRX1 gene (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B:IRX1 gene [nucleoplasm] (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B binds the IRX2 gene (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B:IRX2 gene [nucleoplasm] (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B binds the LFNG gene (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B:LFNG gene [nucleoplasm] (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B binds the WNT9B gene (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B:WNT9B gene [nucleoplasm] (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
Regulation of beta-cell development (Homo sapiens)
Regulation of gene expression in early pancreatic precursor cells (Homo sapiens)
HNF1B- and FGF10-dependent synthesis of PTF1A protein (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
HNF1B-dependent synthesis of HNF6 protein (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells (Homo sapiens)
HNF6-dependent synthesis of HNF1B protein (Homo sapiens)
HNF1B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35680 HNF1B
Gene Names
HNF1B, TCF2
Chain
chain:1-557
Reference Genes
BioGPS Gene:6928 HNF1B
CTD Gene:6928 HNF1B
dbSNP Gene:6928 HNF1B
ENSEMBL:ENSG00000275410 HNF1B
HGNC:11630 HNF1B
KEGG:hsa:6928 HNF1B
Monarch:6928 HNF1B
NCBI Gene:6928 HNF1B
OMIM:189907 HNF1B
UCSC:P35680 HNF1B
Reference Transcript
RefSeq:NM_000458.4 HNF1B
RefSeq:NM_001165923.4 HNF1B
RefSeq:NM_001304286.1 HNF1B
Other Identifiers
11725253_at
11752480_a_at
16843853
205313_PM_at
205313_at
208135_PM_at
208135_at
33621_at
3754795
3754796
3754798
3754799
3754800
3754801
3754805
3754806
3754807
3754808
3754812
3754820
3754821
3754822
3754823
3754824
3754825
3754826
3754827
3754828
3754831
3754832
38506_at
6928
711_at
8014591
A_23_P207557
A_23_P409287
A_24_P330822
GE58405
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0000987
GO:0001221
GO:0001714
GO:0001822
GO:0001826
GO:0001889
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005829
GO:0006355
GO:0006357
GO:0006915
GO:0007219
GO:0007492
GO:0009749
GO:0009952
GO:0010467
GO:0010628
GO:0012501
GO:0022414
GO:0030073
GO:0030111
GO:0030154
GO:0030902
GO:0031016
GO:0031018
GO:0035565
GO:0039020
GO:0042802
GO:0042803
GO:0043066
GO:0043226
GO:0043231
GO:0045893
GO:0045944
GO:0048513
GO:0048557
GO:0048731
GO:0048754
GO:0048793
GO:0048806
GO:0048856
GO:0050673
GO:0060261
GO:0060429
GO:0060677
GO:0060993
GO:0061017
GO:0061296
GO:0072095
GO:0072164
GO:0072176
GO:0072177
GO:0072179
GO:0072181
GO:0140110
GO:1900200
GO:1900212
GO:1990841
HMNXSV003015246
HMNXSV003016098
ILMN_1663561
ILMN_1778337
ILMN_1778941
PH_hs_0024721
TC17001410.hg
X71348_at
g4507396_3p_at
Participates
as a protein marker of
pancreatic ductal cell (Homo sapiens)
primary multipotent pancreatic progenitor cell (Homo sapiens)
as an output of
HNF6-dependent synthesis of HNF1B protein (Homo sapiens)
as an input of
HNF1B binds the LFNG gene (Homo sapiens)
HNF1B binds the HNF4A gene (Homo sapiens)
HNF1B binds the IRX2 gene (Homo sapiens)
HNF1B binds the DLL1 gene (Homo sapiens)
HNF1B binds the IRX1 gene (Homo sapiens)
HNF1B binds the WNT9B gene (Homo sapiens)
as a component of
HNF1B:LFNG gene [nucleoplasm] (Homo sapiens)
HNF1B:HNF1A gene [nucleoplasm] (Homo sapiens)
HNF1B:IRX2 gene [nucleoplasm] (Homo sapiens)
HNF1B:DLL1 gene [nucleoplasm] (Homo sapiens)
HNF1B:IRX1 gene [nucleoplasm] (Homo sapiens)
HNF1B:WNT9B gene [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
HNF1B- and FGF10-dependent synthesis of PTF1A protein
(Homo sapiens)
HNF1B-dependent synthesis of HNF6 protein
(Homo sapiens)
Expression of POU3F3 during nephron development
(Homo sapiens)
Expression of JAG1 during nephron development
(Homo sapiens)
Cross References
RefSeq
NP_000449.1
,
NP_001159395.1
,
NP_001291215.1
OpenTargets
ENSG00000275410
ENSEMBL
ENSG00000275410
,
ENSP00000488080
,
ENST00000610754
,
ENSP00000482711
,
ENST00000617811
,
ENSP00000484591
,
ENSP00000480291
,
ENST00000633792
,
ENST00000621123
,
ENSG00000276194
HPA
ENSG00000275410-HNF1B
GeneCards
HNF1B
PRO
P35680
Pharos - Targets
P35680
Orphanet
HNF1B
PDB
2DA6
,
2H8R
,
5K9S
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61457 PCBD1
1
PCBD1 [cytosol]
(R-HSA-71131)
0.815
8
UniProt:P20823 HNF1A
1
HNF1A [nucleoplasm]
(R-HSA-3004629)
0.564
2
UniProt:Q8TDS5 OXER1
1
OXER1 [plasma membrane]
(R-HSA-416425)
0.556
3
UniProt:O43186 CRX
0.556
3
UniProt:P32243-2 OTX2
0.556
3
UniProt:Q6NVU6 UFSP1
0.556
3
UniProt:Q08AM6 VAC14
3
VAC14 [Golgi membrane]
(R-HSA-1806235)
VAC14 [early endosome membrane]
(R-HSA-1806207)
VAC14 [late endosome membrane]
(R-HSA-1806219)
0.556
3
UniProt:Q6PEX3 KRTAP26-1
1
KRTAP26-1 [cytosol]
(R-HSA-6810244)
0.556
3
UniProt:Q9NP55 BPIFA1
1
BPIFA1 [extracellular region]
(R-HSA-6809280)
0.556
3
UniProt:P55197-2 MLLT10
0.556
3
UniProt:P78424 PO6F2
0.556
3
UniProt:Q70EL1-9 USP54
0.556
3
UniProt:Q5SWW7 CJ055
0.556
3
UniProt:Q9H0N5 PHS2
0.483
2
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