Reactome | lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O

lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O

Stable Identifier

R-HSA-70938

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

2-oxoglutarate + H(+) + L-lysine + NADPH => H2O + L-saccharopine + NADP(+)

ReviewStatus

5/5

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lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O

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The saccharopine dehydrogenase activity of lysine-ketoglutarate reductase / saccharopine dehydrogenase homotetramer in the mitochondrial matrix catalyzes the reaction of lysine, alpha-ketoglutarate, and NADPH + H+ to form saccharopine, NADP+, and H2O (Markovitz et al. 1984; Sacksteder et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
6434529	Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities. Markovitz, PJ, Chuang, DT, Cox, RP	J Biol Chem	1984
10775527	Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia. Biery, BJ, Goodman, BK, Geraghty, MT, Geisbrecht, BV, Gould, SJ, Sacksteder, KA, Morrell, JC, Cox, RP	Am J Hum Genet	2001