Interaction between PHLDA1 and AURKA

Stable Identifier
R-HSA-8854521
DOI
10.3180/r-hsa-8854521.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Interaction between PHLDA1 and AURKA
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PHLDA1 (TDAG51), the product of a gene involved in breast cancer progression, interacts with aurora kinase A (AURKA). While unphosphorylated PHLDA1 promotes AURKA ubiquitination and degradation, AURKA-mediated phosphorylation of PHLDA1 results in down-regulation of PHLDA1 protein levels. Ectopic expression of PHLDA1 strongly antagonizes AURKA-triggered oncogenic phenotypes, suggesting PHLDA1 downregulation as one of the key mechanisms by which AURKA promotes breast cancer (Johnson et al. 2011).
Literature References
PubMed ID Title Journal Year
21807936 PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer

Badve, S, Ghosh, S, Chang, KH, Johnson, EO, Mehta, R, Shah, K, de Pablo, Y

J. Cell. Sci. 2011
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Orthologous Events
Interaction between PHLDA1 and AURKA (Bos taurus)
Interaction between PHLDA1 and AURKA (Canis familiaris)
Interaction between PHLDA1 and AURKA (Danio rerio)
Interaction between PHLDA1 and AURKA (Gallus gallus)
Interaction between PHLDA1 and AURKA (Mus musculus)
Interaction between PHLDA1 and AURKA (Rattus norvegicus)
Interaction between PHLDA1 and AURKA (Sus scrofa)
Interaction between PHLDA1 and AURKA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-29)
Reviewed
Shah, K  (2016-02-04)
Created
Orlic-Milacic, M  (2016-01-27)
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