TPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. 2003, Xu et al. 2011, Giubettini et al. 2011, Dodson and Bayliss 2012).
Dodson, CA, Bayliss, R
Scrofani, J, Asteriti, IA, Lavia, P, Giubettini, M, Lindon, C, De Luca, M, Guarguaglini, G
Sardon, T, Bayliss, R, Conti, E, Vernos, I
Li, Y, Wang, X, Wang, Y, Xiao, Z, Xu, X
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