Reactome | SRRT [nucleoplasm]

SRRT [nucleoplasm]

Stable Identifier

R-HSA-6814858

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Serrate RNA effector molecule homolog, SRRT_HUMAN, ASR2, ARS2B

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus-Host Interactions (Homo sapiens)
        
        NS5 interacts with Spliceosome (Homo sapiens)
        
        NS5:Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        SRRT [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        SRRT [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BXP5 SRRT

Gene Names

SRRT, ARS2, ASR2

Chain

initiator methionine:1, chain:2-876

Reference Genes

BioGPS Gene:51593 SRRT

COSMIC (genes):SRRT SRRT

CTD Gene:51593 SRRT

dbSNP Gene:51593 SRRT

ENSEMBL:ENSG00000087087 SRRT

HGNC:24101 SRRT

KEGG:hsa:51593 SRRT

Monarch:51593 SRRT

NCBI Gene:51593 SRRT

OMIM:614469 SRRT

UCSC:Q9BXP5 SRRT

Reference Transcript

Participates

as a component of

as an input of

as an output of

Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)

Inferred To

srrt [nucleoplasm] (Danio rerio)

Srrt [nucleoplasm] (Mus musculus)

Srrt [nucleoplasm] (Rattus norvegicus)

srrt-1 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of SRRT [nucleoplasm] (Gallus gallus)

Ghost homologue of SRRT [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of SRRT [nucleoplasm] (Xenopus tropicalis)

Ars2 [nucleoplasm] (Drosophila melanogaster)

SRRT [nucleoplasm] (Bos taurus)

SRRT [nucleoplasm] (Canis familiaris)

SRRT [nucleoplasm] (Dictyostelium discoideum)

SRRT [nucleoplasm] (Plasmodium falciparum)

SRRT [nucleoplasm] (Sus scrofa)

pir2 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001122325.1, NP_001122326.1, NP_001122324.1, NP_056992.4

OpenTargets

ENSG00000087087

ENSEMBL

ENST00000618411, ENST00000618262, ENSP00000481173, ENSG00000087087, ENSP00000478341, ENST00000611405, ENSP00000480421, ENST00000614484, ENSP00000483556

HPA

ENSG00000087087-SRRT

GeneCards

SRRT

PRO

Q9BXP5

Pharos - Targets

Q9BXP5

GlyGen

Q9BXP5

PDB

8PMP, 6F7P, 6F7J, 6F8D, 6F7S, 5OO6

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.643	8
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.643	10
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.643	3
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.547	2
UniProt:Q13936 CACNA1C	1	CACNA1C [plasma membrane] (R-HSA-265551)	0.547	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	3
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.527	2
UniProt:Q53F19 NCBP3			0.527	4
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.483	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.483	2
UniProt:Q96FV9 THOC1	1	THOC1 [nucleoplasm] (R-HSA-8849130)	0.462	2

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