CBCAP complex binds 7-methylguanosine cap of snRNA

Stable Identifier
R-HSA-6814885
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CBCAP complex binds 7-methylguanosine cap of snRNA
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As the capped pre-snRNA continues to be elongated, the CBCAP complex comprising NCBP1 (CBP80), NCBP2 (CBP20), SRRT (ARS2) and PHAX binds the 7-methylguanosine cap (Hallais et al. 2013). The CBCAP complex enhances 3' processing of the pre-snRNA (Hallais et al. 2013) and participates in export of the snRNA from the nucleus to the cytosol, where the snRNA is further modified and assembled with proteins into pre-snRNPs.
Literature References
PubMed ID Title Journal Year
24270878 CBC-ARS2 stimulates 3'-end maturation of multiple RNA families and favors cap-proximal processing

Benbahouche, Nel H, Lener, D, Vandermoere, F, Bertrand, E, Verheggen, C, Clerici, M, Hallais, M, Gostan, T, Robert, MC, Jensen, TH, Andersen, PR, Cusack, S, Pontvianne, F

Nat. Struct. Mol. Biol. 2013
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Orthologous Events
CBCAP complex binds 7-methylguanosine cap of snRNA (Bos taurus)
CBCAP complex binds 7-methylguanosine cap of snRNA (Caenorhabditis elegans)
CBCAP complex binds 7-methylguanosine cap of snRNA (Canis familiaris)
CBCAP complex binds 7-methylguanosine cap of snRNA (Drosophila melanogaster)
CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)
CBCAP complex binds 7-methylguanosine cap of snRNA (Rattus norvegicus)
CBCAP complex binds 7-methylguanosine cap of snRNA (Sus scrofa)
Authored
May, B  (2015-11-27)
Reviewed
Hernandez, N  (2016-02-19)
Created
May, B  (2015-11-29)
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