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M6PR [transport vesicle]
Stable Identifier
R-HSA-6814613
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
transport vesicle
Synonyms
Cation-dependent mannose-6-phosphate receptor, MPRD_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Glycosphingolipid metabolism (Homo sapiens)
Glycosphingolipid catabolism (Homo sapiens)
M6PR transports activated ARSA to the lysosome (Homo sapiens)
M6PR [transport vesicle] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Homo sapiens)
RAB9:GTP:PLIN3:p-RABEPK:late-endosome-to-TGN cargo:VAMP3:RHOBTB3:ATP [transport vesicle] (Homo sapiens)
RAB9:GTP:PLIN3:p-RABEPK:late-endosome-to-TGN cargo:VAMP3 [transport vesicle] (Homo sapiens)
late-endosome-to-TGN cargo [transport vesicle] (Homo sapiens)
M6PR dimer [transport vesicle] (Homo sapiens)
M6PR [transport vesicle] (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:late endosome-to-TGN cargo [transport vesicle] (Homo sapiens)
late-endosome-to-TGN cargo [transport vesicle] (Homo sapiens)
M6PR dimer [transport vesicle] (Homo sapiens)
M6PR [transport vesicle] (Homo sapiens)
RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Homo sapiens)
RAB9:GTP:PLIN3:p-RABEPK:late-endosome-to-TGN cargo:VAMP3 [transport vesicle] (Homo sapiens)
late-endosome-to-TGN cargo [transport vesicle] (Homo sapiens)
M6PR dimer [transport vesicle] (Homo sapiens)
M6PR [transport vesicle] (Homo sapiens)
RAB9:GTP:PLIN3:p-RABEPK:late-endosome-to-TGN cargo:VAMP3:RHOBTB3:ATP [transport vesicle] (Homo sapiens)
RAB9:GTP:PLIN3:p-RABEPK:late-endosome-to-TGN cargo:VAMP3 [transport vesicle] (Homo sapiens)
late-endosome-to-TGN cargo [transport vesicle] (Homo sapiens)
M6PR dimer [transport vesicle] (Homo sapiens)
M6PR [transport vesicle] (Homo sapiens)
Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:late endosome-to-TGN cargo [transport vesicle] (Homo sapiens)
late-endosome-to-TGN cargo [transport vesicle] (Homo sapiens)
M6PR dimer [transport vesicle] (Homo sapiens)
M6PR [transport vesicle] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20645 M6PR
Gene Names
M6PR, MPR46, MPRD
Chain
signal peptide:1-26, chain:27-277
Reference Genes
BioGPS Gene:4074 M6PR
COSMIC (genes):M6PR M6PR
CTD Gene:4074 M6PR
dbSNP Gene:4074 M6PR
ENSEMBL:ENSG00000003056 M6PR
HGNC:6752 M6PR
KEGG:hsa:4074 M6PR
Monarch:4074 M6PR
NCBI Gene:4074 M6PR
OMIM:154540 M6PR
UCSC:P20645 M6PR
Reference Transcript
RefSeq:NM_002355.3 M6PR
RefSeq:XM_005253376.2 M6PR
Other Identifiers
11715827_s_at
11715828_a_at
16760981
200900_PM_s_at
200900_s_at
200901_PM_s_at
200901_s_at
32547_at
3416807
3416849
3416850
3416851
3443297
3443298
3443299
3443300
3443301
3443302
3443303
3443304
3443305
3443306
3443307
3443308
3443309
3443310
3443311
3443312
3443313
3443314
3443315
3443316
3443321
3443322
3443323
3443324
3443325
4074
7960933
A_23_P204252
A_24_P210343
GE59814
GO:0004888
GO:0005215
GO:0005515
GO:0005764
GO:0005765
GO:0005768
GO:0005770
GO:0005773
GO:0005794
GO:0005802
GO:0005886
GO:0006622
GO:0006629
GO:0006886
GO:0006898
GO:0007041
GO:0008333
GO:0016020
GO:0016192
GO:0019904
GO:0030133
GO:0030669
GO:0031410
GO:0032588
GO:0033299
GO:0043226
GO:0046479
GO:0048471
GO:0060089
GO:0140318
GO:1901135
GO:1905394
HMNXSV003023231
Hs.75709.0.S1_3p_a_at
ILMN_2084353
PH_hs_0027247
TC12001184.hg
X56253_rna1_at
g10947032_3p_a_at
Participates
as a component of
M6PR dimer [transport vesicle] (Homo sapiens)
Other forms of this molecule
M6PR [clathrin-coated endocytic vesicle membrane]
M6PR [plasma membrane]
M6PR [Golgi membrane]
M6PR [lysosomal membrane]
M6PR [trans-Golgi network membrane]
Inferred To
m6pr [transport vesicle]
(Danio rerio)
m6pr [transport vesicle]
(Xenopus tropicalis)
M6pr [transport vesicle]
(Mus musculus)
M6pr [transport vesicle]
(Rattus norvegicus)
M6PR [transport vesicle]
(Bos taurus)
M6PR [transport vesicle]
(Canis familiaris)
M6PR [transport vesicle]
(Dictyostelium discoideum)
M6PR [transport vesicle]
(Gallus gallus)
M6PR [transport vesicle]
(Schizosaccharomyces pombe)
M6PR [transport vesicle]
(Sus scrofa)
mrrA [transport vesicle]
(Dictyostelium discoideum)
Homologues of M6PR [transport vesicle]
(Dictyostelium discoideum)
Cross References
ENSEMBL
ENST00000000412
,
ENSP00000000412
OpenTargets
ENSG00000003056
HPA
ENSG00000003056-M6PR
ZINC - Substances
MPRD_HUMAN
ZINC target
P20645
PRO
P20645
Pharos - Targets
P20645
GlyGen
P20645
HMDB Protein
HMDBP01753
PDB
1JUQ
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NZ52 GGA3
3
GGA3 [endosome membrane]
(R-HSA-5692936)
GGA3 [early endosome membrane]
(R-HSA-8854137)
GGA3 [recycling endosome membrane]
(R-HSA-8875655)
0.573
2
UniProt:Q96F15 GIMA5
0.556
3
UniProt:Q86UP2-3 KTN1
0.556
3
UniProt:Q9UNI6 DUS12
0.556
3
UniProt:Q9NRQ5 SMCO4
0.556
3
UniProt:P21964-2 COMT
0.556
3
UniProt:Q9NZG7 NINJ2
0.556
3
UniProt:Q96LR4 TAFA4
0.527
2
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