Reactome | M6PR [plasma membrane]

M6PR [plasma membrane]

Stable Identifier

R-HSA-8864564

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Cation-dependent mannose-6-phosphate receptor, MPRD_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - AP-2 directly binds some endocytic cargo (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        AP-2:cargo [plasma membrane] (Homo sapiens)
        
        AP-2 cargo [plasma membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
        
        M6PR [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P20645 M6PR

Gene Names

M6PR, MPR46, MPRD

Chain

signal peptide:1-26, chain:27-277

Reference Genes

BioGPS Gene:4074 M6PR

COSMIC (genes):M6PR M6PR

CTD Gene:4074 M6PR

dbSNP Gene:4074 M6PR

ENSEMBL:ENSG00000003056 M6PR

HGNC:6752 M6PR

KEGG:hsa:4074 M6PR

Monarch:4074 M6PR

NCBI Gene:4074 M6PR

OMIM:154540 M6PR

UCSC:P20645 M6PR

Reference Transcript

Other Identifiers

11715827_s_at

11715828_a_at

16760981

200900_PM_s_at

200900_s_at

200901_PM_s_at

200901_s_at

32547_at

3416807

3416849

3416850

3416851

3443297

3443298

3443299

3443300

3443301

3443302

3443303

3443304

3443305

3443306

3443307

3443308

3443309

3443310

3443311

3443312

3443313

3443314

3443315

3443316

3443321

3443322

3443323

3443324

3443325

4074

7960933

A_23_P204252

A_24_P210343

GE59814

GO:0004888

GO:0005215

GO:0005515

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005773

GO:0005794

GO:0005802

GO:0005886

GO:0006622

GO:0006629

GO:0006886

GO:0006898

GO:0007041

GO:0008333

GO:0016020

GO:0016192

GO:0019904

GO:0030133

GO:0030669

GO:0031410

GO:0032588

GO:0033299

GO:0043226

GO:0046479

GO:0048471

GO:0060089

GO:0140318

GO:1901135

GO:1905394

HMNXSV003023231

Hs.75709.0.S1_3p_a_at

ILMN_2084353

PH_hs_0027247

TC12001184.hg

X56253_rna1_at

g10947032_3p_a_at

Participates

as a member of

AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)

Other forms of this molecule

M6PR [clathrin-coated endocytic vesicle membrane]

M6PR [Golgi membrane]

M6PR [lysosomal membrane]

M6PR [trans-Golgi network membrane]

M6PR [transport vesicle]

Inferred To

M6PR [plasma membrane] (Bos taurus)

M6PR [plasma membrane] (Canis familiaris)

M6PR [plasma membrane] (Dictyostelium discoideum)

M6PR [plasma membrane] (Gallus gallus)

M6PR [plasma membrane] (Schizosaccharomyces pombe)

M6PR [plasma membrane] (Sus scrofa)

m6pr [plasma membrane] (Danio rerio)

m6pr [plasma membrane] (Xenopus tropicalis)

mrrA [plasma membrane] (Dictyostelium discoideum)

ATG27 [plasma membrane] (Saccharomyces cerevisiae)

M6pr [plasma membrane] (Mus musculus)

M6pr [plasma membrane] (Rattus norvegicus)

MRL1 [plasma membrane] (Saccharomyces cerevisiae)

Homologues of M6PR [plasma membrane] (Dictyostelium discoideum)

Homologues of M6PR [plasma membrane] (Saccharomyces cerevisiae)

Cross References

ENSEMBL

ENST00000000412, ENSP00000000412

OpenTargets

ENSG00000003056

HPA

ENSG00000003056-M6PR

ZINC - Substances

MPRD_HUMAN

ZINC target

P20645

PRO

P20645

Pharos - Targets

P20645

GlyGen

P20645

HMDB Protein

HMDBP01753

PDB

1JUQ

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NZ52 GGA3	3	GGA3 [endosome membrane] (R-HSA-5692936) GGA3 [early endosome membrane] (R-HSA-8854137) GGA3 [recycling endosome membrane] (R-HSA-8875655)	0.573	2
UniProt:Q96F15 GIMA5			0.556	3
UniProt:Q86UP2-3 KTN1			0.556	3
UniProt:Q9UNI6 DUS12			0.556	3
UniProt:Q9NRQ5 SMCO4			0.556	3
UniProt:P21964-2 COMT			0.556	3
UniProt:Q9NZG7 NINJ2			0.556	3
UniProt:Q96LR4 TAFA4			0.527	2

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