Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
M6PR [lysosomal membrane]
Stable Identifier
R-HSA-432696
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
Cation-dependent mannose-6-phosphate receptor, MPRD_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
trans-Golgi Network Vesicle Budding (Homo sapiens)
Lysosome Vesicle Biogenesis (Homo sapiens)
trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Homo sapiens)
Lysosome Cargo [lysosomal membrane] (Homo sapiens)
M6PR [lysosomal membrane] (Homo sapiens)
Lysosome Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [lysosomal membrane] (Homo sapiens)
Lysosome Cargo [lysosomal membrane] (Homo sapiens)
M6PR [lysosomal membrane] (Homo sapiens)
trans-Golgi Network Lysosomal Vesicle Scission (Homo sapiens)
Lysosome Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [lysosomal membrane] (Homo sapiens)
Lysosome Cargo [lysosomal membrane] (Homo sapiens)
M6PR [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20645 M6PR
Gene Names
M6PR, MPR46, MPRD
Chain
signal peptide:1-26, chain:27-277
Reference Genes
BioGPS Gene:4074 M6PR
COSMIC (genes):M6PR M6PR
CTD Gene:4074 M6PR
dbSNP Gene:4074 M6PR
ENSEMBL:ENSG00000003056 M6PR
HGNC:6752 M6PR
KEGG:hsa:4074 M6PR
Monarch:4074 M6PR
NCBI Gene:4074 M6PR
OMIM:154540 M6PR
UCSC:P20645 M6PR
Reference Transcript
RefSeq:XM_047428850.1 M6PR
RefSeq:NM_001414333.1 M6PR
RefSeq:XM_005253376.2 M6PR
RefSeq:NM_002355.4 M6PR
RefSeq:NM_001414320.1 M6PR
RefSeq:NM_001414332.1 M6PR
RefSeq:XM_054372054.1 M6PR
RefSeq:NM_001414331.1 M6PR
Other Identifiers
11715827_s_at
11715828_a_at
16760981
200900_PM_s_at
200900_s_at
200901_PM_s_at
200901_s_at
32547_at
3416807
3416849
3416850
3416851
3443297
3443298
3443299
3443300
3443301
3443302
3443303
3443304
3443305
3443306
3443307
3443308
3443309
3443310
3443311
3443312
3443313
3443314
3443315
3443316
3443317
3443318
3443319
3443320
3443321
3443322
3443323
3443324
3443325
3443326
3443327
4074
7960933
A_23_P204252
A_24_P210343
GE59814
GO:0004888
GO:0005215
GO:0005515
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005770
GO:0005794
GO:0005802
GO:0005886
GO:0006622
GO:0006629
GO:0006886
GO:0006898
GO:0007041
GO:0008333
GO:0012505
GO:0016020
GO:0016192
GO:0019904
GO:0030133
GO:0030669
GO:0031410
GO:0032588
GO:0033299
GO:0046479
GO:0048471
GO:0140318
GO:1901135
GO:1905394
HMNXSV003023231
Hs.75709.0.S1_3p_a_at
ILMN_2084353
PH_hs_0027247
TC12001184.hg
X56253_rna1_at
g10947032_3p_a_at
Participates
as a candidate of
Lysosome Cargo [lysosomal membrane] (Homo sapiens)
Other forms of this molecule
M6PR [transport vesicle]
M6PR [plasma membrane]
M6PR [clathrin-coated endocytic vesicle membrane]
M6PR [trans-Golgi network membrane]
M6PR [Golgi membrane]
Inferred To
M6pr [lysosomal membrane]
(Mus musculus)
M6pr [lysosomal membrane]
(Rattus norvegicus)
mrrA [lysosomal membrane]
(Dictyostelium discoideum)
Homologues of M6PR [lysosomal membrane]
(Dictyostelium discoideum)
m6pr [lysosomal membrane]
(Danio rerio)
m6pr [lysosomal membrane]
(Xenopus tropicalis)
M6PR [lysosomal membrane]
(Bos taurus)
M6PR [lysosomal membrane]
(Canis familiaris)
M6PR [lysosomal membrane]
(Dictyostelium discoideum)
M6PR [lysosomal membrane]
(Gallus gallus)
M6PR [lysosomal membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001401262.1
,
NP_002346.1
,
NP_001401249.1
,
XP_047284806.1
,
XP_005253433.1
,
XP_054228029.1
,
NP_001401260.1
,
NP_001401261.1
OpenTargets
ENSG00000003056
ENSEMBL
ENSP00000000412
,
ENSG00000003056
,
ENST00000000412
HPA
ENSG00000003056-M6PR
GeneCards
M6PR
ZINC - Substances
MPRD_HUMAN
ZINC target
P20645
PRO
P20645
Pharos - Targets
P20645
GlyGen
P20645
PDB
1JUQ
HMDB Protein
HMDBP01753
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NZ52 GGA3
3
GGA3 [early endosome membrane]
(R-HSA-8854137)
GGA3 [recycling endosome membrane]
(R-HSA-8875655)
GGA3 [endosome membrane]
(R-HSA-5692936)
0.573
2
UniProt:Q9NZG7 NINJ2
0.556
3
UniProt:P21964-2 COMT
0.556
3
UniProt:Q9NRQ5 SMCO4
0.556
3
UniProt:Q9UNI6 DUS12
0.556
3
UniProt:Q86UP2-3 KTN1
0.556
3
UniProt:Q96F15 GIMA5
0.556
3
UniProt:Q96LR4 TAFA4
0.527
2
UniProt:Q8WXA2 PATE1
0.527
2
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text