Reactome | COPI-dependent Golgi-to-ER retrograde traffic

COPI-dependent Golgi-to-ER retrograde traffic

Stable Identifier

R-HSA-6811434

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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COPI-dependent Golgi-to-ER retrograde traffic

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Retrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed in Lord et al, 2013; Spang et al, 2013). These assemble at the cis side of the Golgi in a GBF-dependent fashion and are tethered at the ER by the ER-specific SNAREs and by the conserved NRZ multisubunit tethering complex, known as DSL in yeast (reviewed in Tagaya et al, 2014; Hong and Lev, 2014). Typical cargo of these retrograde vesicles includes 'escaped' ER chaperone proteins, which are recycled back to the ER for reuse by virtue of their interaction with the Golgi localized KDEL receptors (reviewed in Capitani and Sallese, 2009; Cancino et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
23873287	Regulation of Golgi signaling and trafficking by the KDEL receptor Cancino, J, Jung, JE, Luini, A	Histochem. Cell Biol.	2013
10469566	Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes Shima, DT, Scales, SJ, Kreis, TE, Pepperkok, R	Curr. Biol.	1999
24119662	Tethering the assembly of SNARE complexes Hong, W, Lev, S	Trends Cell Biol.	2014
25364732	Moonlighting functions of the NRZ (mammalian Dsl1) complex Tagaya, M, Arasaki, K, Inoue, H, Kimura, H	Front Cell Dev Biol	2014
23732476	Retrograde traffic from the Golgi to the endoplasmic reticulum Spang, A	Cold Spring Harb Perspect Biol	2013
19854180	The KDEL receptor: new functions for an old protein Capitani, M, Sallese, M	FEBS Lett.	2009
23378591	The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi Lord, C, Ferro-Novick, S, Miller, EA	Cold Spring Harb Perspect Biol	2013
9813082	Reconstitution of retrograde transport from the Golgi to the ER in vitro Spang, A, Schekman, R	J. Cell Biol.	1998
8001155	Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum Letourneur, F, Gaynor, EC, Hennecke, S, Démollière, C, Duden, R, Emr, SD, Riezman, H, Cosson, P	Cell	1994